LCDR

Summary

LCDR (lysosome cell death regulator, HGNC:44308) is a long non-coding RNA gene on chromosome 20p11.23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44308
Approved symbol	LCDR
Name	lysosome cell death regulator
Location	20p11.23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000273148
Ensembl biotype	lncRNA
Entrez	100270804
RNAcentral	URS000075B044 — lncRNA, 2034 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000609087, ENST00000740308, ENST00000740309

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000609087 — 1 exons

Exon	Start	End
ENSE00003986007	18794078	18796067

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 87.71.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2599 / max 75.8131, expressed in 1364 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
183699	4.2599	1364

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.71	gold quality
calcaneal tendon	UBERON:0003701	82.02	gold quality
right uterine tube	UBERON:0001302	78.07	gold quality
left ovary	UBERON:0002119	74.53	gold quality
gastrocnemius	UBERON:0001388	74.21	gold quality
muscle of leg	UBERON:0001383	74.11	gold quality
right ovary	UBERON:0002118	74.10	gold quality
body of uterus	UBERON:0009853	74.06	gold quality
tendon	UBERON:0000043	73.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	73.11	gold quality
lower esophagus	UBERON:0013473	73.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	72.98	gold quality
tibial artery	UBERON:0007610	72.58	gold quality
popliteal artery	UBERON:0002250	72.56	gold quality
apex of heart	UBERON:0002098	72.46	gold quality
tibial nerve	UBERON:0001323	72.42	gold quality
right lobe of thyroid gland	UBERON:0001119	72.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.92	gold quality
mucosa of stomach	UBERON:0001199	71.79	gold quality
epithelium of nasopharynx	UBERON:0001951	71.69	gold quality
right lung	UBERON:0002167	71.44	gold quality
left lobe of thyroid gland	UBERON:0001120	71.30	gold quality
aorta	UBERON:0000947	71.02	gold quality
spleen	UBERON:0002106	71.02	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.73	gold quality
thyroid gland	UBERON:0002046	70.64	gold quality
body of stomach	UBERON:0001161	70.36	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.97	gold quality
ovary	UBERON:0000992	69.81	gold quality
left uterine tube	UBERON:0001303	69.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.