LCT-AS1

Summary

LCT-AS1 (LCT antisense RNA 1, HGNC:40337) is a long non-coding RNA gene on chromosome 2q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40337
Approved symbol	LCT-AS1
Name	LCT antisense RNA 1
Location	2q21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226806
Ensembl biotype	lncRNA
Entrez	100507600
RNAcentral	URS0000114194 — lncRNA, 1862 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000437007, ENST00000769912, ENST00000769913

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000437007 — 2 exons

Exon	Start	End
ENSE00004131459	135820191	135820639
ENSE00004131463	135821675	135823095

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 83.23.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4347 / max 213.5557, expressed in 67 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22667	0.2330	30
22666	0.1783	32
22668	0.0175	6
22665	0.0060	3

Top tissues by expression

161 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	83.23	gold quality
monocyte	CL:0000576	56.95	gold quality
lymph node	UBERON:0000029	55.91	gold quality
cartilage tissue	UBERON:0002418	54.53	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	53.61	gold quality
vermiform appendix	UBERON:0001154	51.09	gold quality
duodenum	UBERON:0002114	49.96	gold quality
small intestine	UBERON:0002108	49.94	gold quality
caecum	UBERON:0001153	47.71	gold quality
intestine	UBERON:0000160	47.46	gold quality
tonsil	UBERON:0002372	47.38	gold quality
gall bladder	UBERON:0002110	46.86	gold quality
colon	UBERON:0001155	46.66	gold quality
large intestine	UBERON:0000059	45.45	gold quality
upper leg skin	UBERON:0004262	44.87	silver quality
oocyte	CL:0000023	44.79	gold quality
adrenal gland	UBERON:0002369	44.67	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
spleen	UBERON:0002106	42.37	silver quality
urinary bladder	UBERON:0001255	42.16	gold quality
thyroid gland	UBERON:0002046	42.02	gold quality
bone marrow	UBERON:0002371	42.02	gold quality
cortex of kidney	UBERON:0001225	41.99	silver quality
heart left ventricle	UBERON:0002084	41.97	gold quality
palpebral conjunctiva	UBERON:0001812	41.76	gold quality
anatomical system	UBERON:0000467	41.59	gold quality
material anatomical entity	UBERON:0000465	41.50	gold quality
multicellular organism	UBERON:0000468	41.50	gold quality
vastus lateralis	UBERON:0001379	41.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LOC100507600 serves as a miR128-1-3p sponge and influence the expression of the miR128-1-3p target gene BMI1. (PMID:29429387)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.