LDLRAD4-AS1

Summary

LDLRAD4-AS1 (LDLRAD4 antisense RNA 1, HGNC:48592) is a long non-coding RNA gene on chromosome 18p11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48592
Approved symbol	LDLRAD4-AS1
Name	LDLRAD4 antisense RNA 1
Location	18p11.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000267690
Ensembl biotype	lncRNA
Entrez	100288122
RNAcentral	URS000075C448 — lncRNA, 2196 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000588672, ENST00000818564

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000588672 — 4 exons

Exon	Start	End
ENSE00002741760	13423575	13423693
ENSE00002776005	13427380	13427480
ENSE00002815900	13419421	13421208
ENSE00002830883	13425932	13426113

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 74.82.

Top tissues by expression

214 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.82	gold quality
tendon of biceps brachii	UBERON:0008188	71.57	silver quality
thoracic aorta	UBERON:0001515	66.09	gold quality
ascending aorta	UBERON:0001496	65.91	gold quality
buccal mucosa cell	CL:0002336	65.00	silver quality
descending thoracic aorta	UBERON:0002345	64.71	gold quality
oviduct epithelium	UBERON:0004804	63.15	gold quality
sural nerve	UBERON:0015488	62.31	silver quality
bone marrow cell	CL:0002092	60.70	silver quality
aorta	UBERON:0000947	59.59	gold quality
sperm	CL:0000019	59.40	gold quality
tendon	UBERON:0000043	59.08	gold quality
ganglionic eminence	UBERON:0004023	57.39	silver quality
medial globus pallidus	UBERON:0002477	56.88	gold quality
cartilage tissue	UBERON:0002418	56.12	gold quality
globus pallidus	UBERON:0001875	55.96	gold quality
calcaneal tendon	UBERON:0003701	55.59	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.29	gold quality
popliteal artery	UBERON:0002250	54.28	gold quality
fallopian tube	UBERON:0003889	54.24	gold quality
tibial artery	UBERON:0007610	54.20	gold quality
substantia nigra	UBERON:0002038	53.91	gold quality
midbrain	UBERON:0001891	53.77	gold quality
urethra	UBERON:0000057	53.69	gold quality
nipple	UBERON:0002030	53.63	gold quality
saphenous vein	UBERON:0007318	53.52	gold quality
pericardium	UBERON:0002407	53.40	gold quality
right lobe of liver	UBERON:0001114	53.22	gold quality
thymus	UBERON:0002370	53.19	gold quality
trigeminal ganglion	UBERON:0001675	53.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer. (PMID:32111819)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.