LEF1-AS1

Summary

LEF1-AS1 (LEF1 antisense RNA 1, HGNC:40339) is a long non-coding RNA gene on chromosome 4q25.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40339
Approved symbol	LEF1-AS1
Name	LEF1 antisense RNA 1
Location	4q25
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232021
Ensembl biotype	lncRNA
Entrez	641518
RNAcentral	URS000075CA92 — lncRNA, 1695 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 85 — 84 lncRNA, 1 retained_intron

ENST00000436413, ENST00000506314, ENST00000507799, ENST00000508266, ENST00000508286, ENST00000512129, ENST00000512637, ENST00000659790, ENST00000665040, ENST00000687804, ENST00000692331, ENST00000693123, ENST00000693606, ENST00000700844, ENST00000732953, ENST00000732954, ENST00000732955, ENST00000732956, ENST00000732957, ENST00000732958, ENST00000732959, ENST00000732960, ENST00000732961, ENST00000732962, ENST00000732963, ENST00000732964, ENST00000732965, ENST00000732966, ENST00000732967, ENST00000732968, ENST00000732969, ENST00000732970, ENST00000732971, ENST00000732972, ENST00000732973, ENST00000732974, ENST00000732975, ENST00000732976, ENST00000732977, ENST00000732978, ENST00000732979, ENST00000732980, ENST00000732981, ENST00000732982, ENST00000732983, ENST00000732984, ENST00000732985, ENST00000732986, ENST00000732987, ENST00000732988, ENST00000732989, ENST00000732990, ENST00000732991, ENST00000732992, ENST00000732993, ENST00000732994, ENST00000732996, ENST00000732997, ENST00000732998, ENST00000732999, ENST00000733000, ENST00000733016, ENST00000733018, ENST00000733020, ENST00000733022, ENST00000733024, ENST00000733026, ENST00000733028, ENST00000733029, ENST00000733030, ENST00000733031, ENST00000733032, ENST00000733033, ENST00000733034, ENST00000733035, ENST00000733036, ENST00000733037, ENST00000733038, ENST00000733039, ENST00000733040, ENST00000733041, ENST00000733042, ENST00000733043, ENST00000733044, ENST00000733045

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000436413 — 3 exons

Exon	Start	End
ENSE00001689677	108173419	108173519
ENSE00004063866	108175792	108176430
ENSE00004063993	108167525	108167833

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 99.13.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3076 / max 181.1509, expressed in 211 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
49209	0.6352	110
49206	0.2546	66
49208	0.1007	45
49210	0.0948	22
49207	0.0922	37
49205	0.0879	46
49211	0.0422	10

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	99.13	gold quality
left testis	UBERON:0004533	92.79	gold quality
right testis	UBERON:0004534	92.58	gold quality
testis	UBERON:0000473	90.79	gold quality
adult organism	UBERON:0007023	87.27	gold quality
thymus	UBERON:0002370	77.16	gold quality
tibia	UBERON:0000979	74.33	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	72.68	gold quality
bone marrow cell	CL:0002092	70.63	silver quality
blood	UBERON:0000178	68.14	gold quality
sural nerve	UBERON:0015488	67.75	silver quality
cardiac muscle of right atrium	UBERON:0003379	67.12	gold quality
left ventricle myocardium	UBERON:0006566	67.04	gold quality
ganglionic eminence	UBERON:0004023	66.87	gold quality
tibialis anterior	UBERON:0001385	66.82	silver quality
bone marrow	UBERON:0002371	65.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.76	gold quality
kidney epithelium	UBERON:0004819	63.60	gold quality
lymph node	UBERON:0000029	62.76	gold quality
nasal cavity epithelium	UBERON:0005384	62.33	gold quality
pigmented layer of retina	UBERON:0001782	61.54	silver quality
right adrenal gland cortex	UBERON:0035827	60.90	gold quality
granulocyte	CL:0000094	60.87	gold quality
right adrenal gland	UBERON:0001233	60.81	gold quality
nasal cavity mucosa	UBERON:0001826	60.64	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.43	gold quality
left adrenal gland cortex	UBERON:0035825	60.35	gold quality
endometrium	UBERON:0001295	60.29	gold quality
left adrenal gland	UBERON:0001234	60.26	gold quality
adult mammalian kidney	UBERON:0000082	60.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 18)

• LEF1-AS1/miR-544a/FOXP1 axis is an important contributor to lung cancer progression. Collectively, our novel data uncovers a new mechanism that governs tumor progression in lung cancer and provides new targets that may be used for disease monitoring and therapeutic intervention of lung cancer. (PMID:30734202)
• Low LEF1-AS1 expression is associated with myeloid malignancy. (PMID:30770626)
• LncRNA LEF1-AS1 regulates the migration and proliferation of vascular smooth muscle cells by targeting miR-544a/PTEN axis. (PMID:31016789)
• LEF1-AS1 promotes progression of non-small-cell lung cancer by regulating the miR-489/SOX4 pathway. (PMID:31386568)
• RP11-296E3.2 and LEF1-AS1 could separately serve as potential novel diagnosis and prognostic markers for colorectal cancer metastasis. (PMID:31536481)
• Long noncoding RNA LEF1-AS1 binds with HNRNPL to boost the proliferation, migration, and invasion in osteosarcoma by enhancing the mRNA stability of LEF1. (PMID:31930565)
• Long non-coding RNA LEF1-AS1 is involved in the progression of retinoblastoma through regulating the Wnt/beta-catenin pathway. (PMID:31990064)
• LncRNA LEF1-AS1 silencing diminishes EZH2 expression to delay hepatocellular carcinoma development by impairing CEBPB-interaction with CDCA7. (PMID:32178558)
• LEF1-AS1 is implicated in the malignant development of glioblastoma via sponging miR-543 to upregulate EN2. (PMID:32184164)
• CREB1-induced lncRNA LEF1-AS1 contributes to colorectal cancer progression via the miR-489/DIAPH1 axis. (PMID:32248974)
• LncRNA LEF1-AS1 promotes osteogenic differentiation of dental pulp stem cells via sponging miR-24-3p. (PMID:32780211)
• Long noncoding RNA LEF1-AS1 acts as a microRNA-10a-5p regulator to enhance MSI1 expression and promote chemoresistance in hepatocellular carcinoma cells through activating AKT signaling pathway. (PMID:32786108)
• LEF1-AS1 accelerates tumorigenesis in glioma by sponging miR-489-3p to enhance HIGD1A. (PMID:32826866)
• LncRNA LEF1-AS1/LEF1/FUT8 Axis Mediates Colorectal Cancer Progression by Regulating alpha1, 6-Fucosylationvia Wnt/beta-Catenin Pathway. (PMID:34021424)
• lncRNA LEF1-AS1 Acts as a Novel Biomarker and Promotes Hypopharyngeal Squamous Cell Carcinoma Progression and Metastasis by Targeting the miR-221-5p/GJA1 Axis. (PMID:35371339)
• Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis. (PMID:35563178)
• Cancer-testis non-coding RNA LEF1-AS1 regulates the nuclear translocation of PDCD5 and suppresses its interaction with p53 signaling: a novel target for immunotherapy in esophageal squamous cell carcinoma. (PMID:36827466)
• Mechanism of LEF1-AS1 regulating HUVEC cells by targeting miR-489-3p/S100A11 axis. (PMID:37927791)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.