LEISA1

Summary

LEISA1 (lncRNA enhancing IL-6/STAT3 signaling activation 1, HGNC:55264) is a long non-coding RNA gene on chromosome 11p15.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55264
Approved symbol	LEISA1
Name	lncRNA enhancing IL-6/STAT3 signaling activation 1
Location	11p15.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	LEISA
Ensembl gene	ENSG00000270607
Ensembl biotype	lncRNA
Entrez	100126784
RNAcentral	URS000075CF88 — lncRNA, 3753 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000603468

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000603468 — 1 exons

Exon	Start	End
ENSE00003683685	19710934	19712619

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 89.94.

FANTOM5 (CAGE): breadth broad, TPM avg 5.3021 / max 78.9429, expressed in 888 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118993	4.0271	824
118995	1.0387	367
118994	0.1679	74
118992	0.0685	33

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.94	gold quality
endothelial cell	CL:0000115	85.46	silver quality
ascending aorta	UBERON:0001496	84.45	gold quality
thoracic aorta	UBERON:0001515	84.26	gold quality
descending thoracic aorta	UBERON:0002345	82.78	gold quality
prefrontal cortex	UBERON:0000451	82.04	gold quality
right frontal lobe	UBERON:0002810	80.95	gold quality
aorta	UBERON:0000947	80.90	gold quality
anterior cingulate cortex	UBERON:0009835	80.18	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.81	gold quality
tibial artery	UBERON:0007610	78.57	gold quality
popliteal artery	UBERON:0002250	78.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	78.19	gold quality
neocortex	UBERON:0001950	77.84	gold quality
frontal cortex	UBERON:0001870	77.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.56	silver quality
right coronary artery	UBERON:0001625	76.37	gold quality
amygdala	UBERON:0001876	75.00	gold quality
cerebral cortex	UBERON:0000956	74.73	gold quality
left coronary artery	UBERON:0001626	74.36	gold quality
cortical plate	UBERON:0005343	74.17	gold quality
hypothalamus	UBERON:0001898	73.83	gold quality
coronary artery	UBERON:0001621	73.37	gold quality
epithelial cell of pancreas	CL:0000083	72.34	gold quality
primary visual cortex	UBERON:0002436	72.24	gold quality
substantia nigra	UBERON:0002038	71.67	gold quality
forebrain	UBERON:0001890	71.57	gold quality
cartilage tissue	UBERON:0002418	71.45	gold quality
brain	UBERON:0000955	70.57	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.