LEMD1-AS1

Summary

LEMD1-AS1 (LEMD1 antisense RNA 1, HGNC:44132) is a long non-coding RNA gene on chromosome 1q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44132
Approved symbol	LEMD1-AS1
Name	LEMD1 antisense RNA 1
Location	1q32.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226235
Ensembl biotype	lncRNA
Entrez	284576
RNAcentral	URS00003ED227 — lncRNA, 2781 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000447832, ENST00000813436, ENST00000813437, ENST00000813438, ENST00000813439, ENST00000813440, ENST00000813441

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000447832 — 4 exons

Exon	Start	End
ENSE00001671812	205385233	205387440
ENSE00001733721	205379054	205379325
ENSE00001763095	205373252	205373434
ENSE00002365767	205382027	205382144

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 80.68.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0143 / max 4.3676, expressed in 7 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8031	0.0143	7

Top tissues by expression

177 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	80.68	gold quality
ovary	UBERON:0000992	78.97	gold quality
right adrenal gland cortex	UBERON:0035827	78.79	gold quality
right adrenal gland	UBERON:0001233	78.24	gold quality
adrenal cortex	UBERON:0001235	77.45	gold quality
left adrenal gland cortex	UBERON:0035825	76.66	gold quality
metanephros	UBERON:0000081	76.15	gold quality
left adrenal gland	UBERON:0001234	76.04	gold quality
adrenal gland	UBERON:0002369	75.97	gold quality
right ovary	UBERON:0002118	74.94	gold quality
adrenal tissue	UBERON:0018303	67.99	gold quality
germinal epithelium of ovary	UBERON:0001304	63.12	gold quality
right testis	UBERON:0004534	60.63	gold quality
testis	UBERON:0000473	60.37	gold quality
left testis	UBERON:0004533	60.18	gold quality
cortical plate	UBERON:0005343	59.24	silver quality
ganglionic eminence	UBERON:0004023	57.68	silver quality
female reproductive system	UBERON:0000474	55.96	gold quality
Brodmann (1909) area 9	UBERON:0013540	51.77	gold quality
lower lobe of lung	UBERON:0008949	51.53	silver quality
cerebellar cortex	UBERON:0002129	50.22	silver quality
cerebellar hemisphere	UBERON:0002245	50.20	silver quality
cerebellum	UBERON:0002037	49.48	silver quality
right hemisphere of cerebellum	UBERON:0014890	49.13	silver quality
muscle of leg	UBERON:0001383	48.69	gold quality
left uterine tube	UBERON:0001303	48.47	gold quality
gastrocnemius	UBERON:0001388	48.17	gold quality
oviduct epithelium	UBERON:0004804	48.06	silver quality
islet of Langerhans	UBERON:0000006	47.88	silver quality
lymph node	UBERON:0000029	47.08	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA LEMD1-AS1 relieves chondrocyte inflammation by targeting miR-944/PGAP1 in osteoarthritis. (PMID:35686740)
• Long Noncoding RNA LEMD1-AS1 Increases LEMD1 Expression and Activates PI3K-AKT Pathway to Promote Metastasis in Oral Squamous Cell Carcinoma. (PMID:35983249)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.