LEMD1-DT

Summary

LEMD1-DT (LEMD1 divergent transcript, HGNC:27631) is a long non-coding RNA gene on chromosome 1q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27631
Approved symbol	LEMD1-DT
Name	LEMD1 divergent transcript
Location	1q32.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224717
Ensembl biotype	lncRNA
Entrez	284577
RNAcentral	URS00008BDA32 — lncRNA, 2756 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000442318

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442318 — 3 exons

Exon	Start	End
ENSE00001618896	205456892	205457077
ENSE00001697705	205466621	205469024
ENSE00001759376	205455929	205456223

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 72.40.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0928 / max 7.4454, expressed in 52 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8032	0.0928	52

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	72.40	gold quality
ventricular zone	UBERON:0003053	69.45	gold quality
cortical plate	UBERON:0005343	68.35	gold quality
skin of leg	UBERON:0001511	62.09	gold quality
cerebellum	UBERON:0002037	59.07	gold quality
cerebellar cortex	UBERON:0002129	59.00	gold quality
cerebellar hemisphere	UBERON:0002245	58.85	gold quality
right hemisphere of cerebellum	UBERON:0014890	57.70	gold quality
prostate gland	UBERON:0002367	56.28	gold quality
skeletal muscle tissue	UBERON:0001134	54.47	gold quality
saliva-secreting gland	UBERON:0001044	52.02	silver quality
prefrontal cortex	UBERON:0000451	51.44	silver quality
multicellular organism	UBERON:0000468	49.61	gold quality
frontal cortex	UBERON:0001870	49.15	silver quality
muscle of leg	UBERON:0001383	48.52	silver quality
cerebral cortex	UBERON:0000956	48.43	gold quality
gastrocnemius	UBERON:0001388	46.51	silver quality
islet of Langerhans	UBERON:0000006	44.89	silver quality
adrenal gland	UBERON:0002369	44.84	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	44.73	silver quality
ovary	UBERON:0000992	44.63	silver quality
hypothalamus	UBERON:0001898	44.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	44.38	gold quality
right frontal lobe	UBERON:0002810	43.89	gold quality
left ovary	UBERON:0002119	43.82	silver quality
superior frontal gyrus	UBERON:0002661	42.98	silver quality
right ovary	UBERON:0002118	42.97	silver quality
heart	UBERON:0000948	42.69	silver quality
thyroid gland	UBERON:0002046	42.45	silver quality
heart left ventricle	UBERON:0002084	41.65	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.79

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.