LERFS

Summary

LERFS (lncRNA negative regulator of fibroblast-like synoviocyte migration, SYNCRIP interacting, HGNC:51182) is a long non-coding RNA gene on chromosome 9q13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51182
Approved symbol	LERFS
Name	lncRNA negative regulator of fibroblast-like synoviocyte migration, SYNCRIP interacting
Location	9q13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234665
Ensembl biotype	lncRNA
Entrez	403323
RNAcentral	URS000075DE51 — lncRNA, 1448 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 68 — 68 lncRNA

ENST00000438699, ENST00000445604, ENST00000585533, ENST00000586625, ENST00000590130, ENST00000591993, ENST00000609749, ENST00000612590, ENST00000653936, ENST00000654225, ENST00000654882, ENST00000658257, ENST00000662817, ENST00000664229, ENST00000665356, ENST00000666775, ENST00000667349, ENST00000667498, ENST00000669453, ENST00000670636, ENST00000849141, ENST00000849142, ENST00000849143, ENST00000849144, ENST00000849145, ENST00000849146, ENST00000849147, ENST00000849148, ENST00000849149, ENST00000849150, ENST00000849151, ENST00000849152, ENST00000849153, ENST00000849154, ENST00000849155, ENST00000849156, ENST00000849157, ENST00000849158, ENST00000849159, ENST00000849160, ENST00000849161, ENST00000849162, ENST00000849163, ENST00000849164, ENST00000849165, ENST00000849166, ENST00000849167, ENST00000849168, ENST00000849169, ENST00000849170, ENST00000849171, ENST00000849172, ENST00000849173, ENST00000849174, ENST00000849175, ENST00000849176, ENST00000849177, ENST00000849178, ENST00000849179, ENST00000849180, ENST00000849181, ENST00000849182, ENST00000849183, ENST00000849184, ENST00000849185, ENST00000849186, ENST00000849187, ENST00000849575

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438699 — 4 exons

Exon	Start	End
ENSE00001648608	62869190	62869304
ENSE00001671640	62867708	62868233
ENSE00001762484	62873367	62873691
ENSE00003711425	62876550	62876614

Expression profiles

Bgee: expression breadth ubiquitous, 192 present calls, max score 90.18.

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lateral globus pallidus	UBERON:0002476	90.18	gold quality
kidney epithelium	UBERON:0004819	89.53	gold quality
upper arm skin	UBERON:0004263	88.41	gold quality
lateral nuclear group of thalamus	UBERON:0002736	88.04	gold quality
substantia nigra pars reticulata	UBERON:0001966	87.90	gold quality
left ventricle myocardium	UBERON:0006566	86.50	gold quality
substantia nigra pars compacta	UBERON:0001965	86.23	silver quality
vena cava	UBERON:0004087	85.88	silver quality
cardiac muscle of right atrium	UBERON:0003379	85.85	gold quality
epithelial cell of pancreas	CL:0000083	84.16	gold quality
subthalamic nucleus	UBERON:0001906	83.75	silver quality
dorsal plus ventral thalamus	UBERON:0001897	83.04	silver quality
pancreatic ductal cell	CL:0002079	82.91	silver quality
pons	UBERON:0000988	82.30	silver quality
buccal mucosa cell	CL:0002336	81.86	silver quality
inferior vagus X ganglion	UBERON:0005363	81.46	silver quality
cerebellar vermis	UBERON:0004720	80.97	gold quality
thymus	UBERON:0002370	79.89	silver quality
superior surface of tongue	UBERON:0007371	79.81	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.71	gold quality
sperm	CL:0000019	79.60	gold quality
pericardium	UBERON:0002407	79.44	gold quality
trachea	UBERON:0003126	78.46	gold quality
synovial joint	UBERON:0002217	77.81	gold quality
nasal cavity epithelium	UBERON:0005384	77.78	gold quality
quadriceps femoris	UBERON:0001377	77.75	gold quality
saphenous vein	UBERON:0007318	77.67	gold quality
vastus lateralis	UBERON:0001379	77.57	gold quality
penis	UBERON:0000989	77.34	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.56

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• findings suggest that a decrease in synovial LERFS may contribute to synovial aggression and joint destruction in RA and that targeting the lncRNA LERFS may have therapeutic potential in patients with RA. (PMID:30198906)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.