LGALS8-AS1

Summary

LGALS8-AS1 (LGALS8 antisense RNA 1, HGNC:40340) is a long non-coding RNA gene on chromosome 1q43.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40340
Approved symbol	LGALS8-AS1
Name	LGALS8 antisense RNA 1
Location	1q43
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223776
Ensembl biotype	lncRNA
Entrez	100287902
RNAcentral	URS000075A2FE — lncRNA, 1459 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000487567, ENST00000493812

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000487567 — 1 exons

Exon	Start	End
ENSE00001939667	236523052	236524508

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 87.60.

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	87.60	silver quality
tibialis anterior	UBERON:0001385	83.73	silver quality
endothelial cell	CL:0000115	82.54	silver quality
ileal mucosa	UBERON:0000331	75.52	gold quality
deltoid	UBERON:0001476	68.66	silver quality
epithelial cell of pancreas	CL:0000083	68.20	gold quality
secondary oocyte	CL:0000655	63.69	gold quality
cortical plate	UBERON:0005343	62.16	silver quality
colonic epithelium	UBERON:0000397	59.74	silver quality
amniotic fluid	UBERON:0000173	58.51	gold quality
biceps brachii	UBERON:0001507	58.23	gold quality
quadriceps femoris	UBERON:0001377	56.69	gold quality
ganglionic eminence	UBERON:0004023	55.79	silver quality
apex of heart	UBERON:0002098	55.08	gold quality
granulocyte	CL:0000094	55.03	gold quality
nasal cavity epithelium	UBERON:0005384	55.02	gold quality
heart left ventricle	UBERON:0002084	54.91	gold quality
cardiac ventricle	UBERON:0002082	54.71	gold quality
placenta	UBERON:0001987	54.69	gold quality
heart right ventricle	UBERON:0002080	54.65	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
upper leg skin	UBERON:0004262	54.29	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
vastus lateralis	UBERON:0001379	53.77	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
mucosa of transverse colon	UBERON:0004991	53.45	gold quality
palpebral conjunctiva	UBERON:0001812	53.30	gold quality
vena cava	UBERON:0004087	53.13	gold quality
leukocyte	CL:0000738	52.81	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer. (PMID:36807469)
• Long noncoding RNA LGALS8-AS1 promotes angiogenesis and brain metastases in non-small cell lung cancer. (PMID:37716002)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.