LHFPL3-AS1

Summary

LHFPL3-AS1 (LHFPL3 antisense RNA 1, HGNC:40341) is a long non-coding RNA gene on chromosome 7q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40341
Approved symbol	LHFPL3-AS1
Name	LHFPL3 antisense RNA 1
Location	7q22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226869
Ensembl biotype	lncRNA
Entrez	645591
RNAcentral	URS000075B6EA — lncRNA, 1334 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 lncRNA, 1 retained_intron

ENST00000411448, ENST00000416376, ENST00000417290, ENST00000433514, ENST00000434579, ENST00000449764, ENST00000450896

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411448 — 4 exons

Exon	Start	End
ENSE00001594514	104803956	104804086
ENSE00001624138	104768669	104769016
ENSE00001759602	104799818	104800069
ENSE00001788576	104802839	104802963

Expression profiles

Bgee: expression breadth ubiquitous, 149 present calls, max score 64.77.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6180 / max 517.6791, expressed in 26 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85400	0.4010	24
85399	0.1700	16
85398	0.0315	9
85394	0.0155	9

Top tissues by expression

220 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper leg skin	UBERON:0004262	64.77	gold quality
colonic epithelium	UBERON:0000397	64.50	silver quality
ventricular zone	UBERON:0003053	64.28	gold quality
metanephros cortex	UBERON:0010533	63.63	gold quality
lower lobe of lung	UBERON:0008949	62.69	silver quality
ganglionic eminence	UBERON:0004023	61.78	gold quality
calcaneal tendon	UBERON:0003701	60.23	gold quality
cortex of kidney	UBERON:0001225	59.21	gold quality
corpus callosum	UBERON:0002336	59.21	gold quality
skin of abdomen	UBERON:0001416	59.09	gold quality
tendon of biceps brachii	UBERON:0008188	57.89	gold quality
adult mammalian kidney	UBERON:0000082	57.74	gold quality
right lung	UBERON:0002167	57.19	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.04	gold quality
metanephros	UBERON:0000081	56.74	gold quality
monocyte	CL:0000576	55.99	gold quality
epithelium of nasopharynx	UBERON:0001951	55.94	gold quality
sural nerve	UBERON:0015488	55.87	silver quality
hindlimb stylopod muscle	UBERON:0004252	55.73	gold quality
tendon	UBERON:0000043	55.60	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.54	gold quality
kidney	UBERON:0002113	55.53	gold quality
cerebellar vermis	UBERON:0004720	55.25	gold quality
vermiform appendix	UBERON:0001154	54.72	gold quality
stromal cell of endometrium	CL:0002255	54.51	silver quality
endometrium	UBERON:0001295	54.18	gold quality
pigmented layer of retina	UBERON:0001782	54.05	silver quality
lymph node	UBERON:0000029	53.52	gold quality
zone of skin	UBERON:0000014	53.48	gold quality
smooth muscle tissue	UBERON:0001135	53.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.53

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway. (PMID:33149126)
• Down-regulated long non-coding RNA LHFPL3 antisense RNA 1 inhibits the radiotherapy resistance of nasopharyngeal carcinoma via modulating microRNA-143-5p/homeobox A6 axis. (PMID:35176945)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.