LHX1-DT

Summary

LHX1-DT (LHX1 divergent transcript, HGNC:53778) is a long non-coding RNA gene on chromosome 17q12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53778
Approved symbol	LHX1-DT
Name	LHX1 divergent transcript
Location	17q12
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-ACACA-1
Ensembl gene	ENSG00000277268
Ensembl biotype	lncRNA
Entrez	102723471
RNAcentral	URS0000A76412 — lncRNA, 508 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000612281, ENST00000614277, ENST00000616341, ENST00000621428, ENST00000664845, ENST00000669023, ENST00000671186, ENST00000768378, ENST00000789541, ENST00000789542, ENST00000789543, ENST00000789544, ENST00000816202

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612281 — 4 exons

Exon	Start	End
ENSE00003712632	36907288	36907539
ENSE00003714133	36933204	36933396
ENSE00003732447	36927700	36927805
ENSE00003733904	36936564	36936652

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 96.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4525 / max 76.4368, expressed in 182 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
165458	0.2792	110
165457	0.1235	49
208162	0.0498	17

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar cortex	UBERON:0002129	96.19	gold quality
cerebellar hemisphere	UBERON:0002245	96.19	gold quality
cerebellum	UBERON:0002037	96.17	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.74	gold quality
adult mammalian kidney	UBERON:0000082	85.84	gold quality
kidney	UBERON:0002113	84.62	gold quality
cortex of kidney	UBERON:0001225	78.94	gold quality
metanephros cortex	UBERON:0010533	78.08	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	71.39	gold quality
sural nerve	UBERON:0015488	69.74	gold quality
hypothalamus	UBERON:0001898	69.21	gold quality
ganglionic eminence	UBERON:0004023	66.23	gold quality
substantia nigra	UBERON:0002038	65.66	gold quality
right uterine tube	UBERON:0001302	64.30	gold quality
skeletal muscle tissue	UBERON:0001134	64.10	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.90	gold quality
brain	UBERON:0000955	63.26	gold quality
ventricular zone	UBERON:0003053	62.53	gold quality
fallopian tube	UBERON:0003889	62.41	gold quality
endocervix	UBERON:0000458	61.32	gold quality
left uterine tube	UBERON:0001303	59.28	gold quality
liver	UBERON:0002107	56.68	gold quality
monocyte	CL:0000576	56.63	gold quality
multicellular organism	UBERON:0000468	53.89	gold quality
blood	UBERON:0000178	52.83	gold quality
ovary	UBERON:0000992	51.34	gold quality
prefrontal cortex	UBERON:0000451	51.33	gold quality
left ovary	UBERON:0002119	50.85	gold quality
islet of Langerhans	UBERON:0000006	50.27	gold quality
myometrium	UBERON:0001296	50.14	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.