LHX5-AS1

Summary

LHX5-AS1 (LHX5 antisense RNA 1, HGNC:49570) is a long non-coding RNA gene on chromosome 12q24.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49570
Approved symbol	LHX5-AS1
Name	LHX5 antisense RNA 1
Location	12q24.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	locus4010
Ensembl gene	ENSG00000257935
Ensembl biotype	lncRNA
Entrez	104355219
RNAcentral	URS00007E4C48 — lncRNA, 379 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 58 — 58 lncRNA

ENST00000551357, ENST00000685579, ENST00000688023, ENST00000688463, ENST00000688482, ENST00000688833, ENST00000690089, ENST00000690307, ENST00000690870, ENST00000690921, ENST00000691387, ENST00000693028, ENST00000743755, ENST00000743756, ENST00000743757, ENST00000743758, ENST00000743759, ENST00000743760, ENST00000743761, ENST00000743762, ENST00000743763, ENST00000743764, ENST00000743765, ENST00000743766, ENST00000743767, ENST00000743768, ENST00000743769, ENST00000743770, ENST00000743771, ENST00000743772, ENST00000743773, ENST00000743774, ENST00000743775, ENST00000743776, ENST00000743777, ENST00000743778, ENST00000743780, ENST00000743781, ENST00000743782, ENST00000743783, ENST00000743784, ENST00000743785, ENST00000743786, ENST00000743787, ENST00000743788, ENST00000743789, ENST00000743790, ENST00000743791, ENST00000743792, ENST00000743793, ENST00000743794, ENST00000743795, ENST00000743796, ENST00000743797, ENST00000743798, ENST00000743799, ENST00000743800, ENST00000743801

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000551357 — 2 exons

Exon	Start	End
ENSE00002376974	113480183	113480636
ENSE00004082516	113471922	113472082

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 91.09.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 4.6294 / max 442.4410, expressed in 173 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128197	4.0183	170
128198	0.3665	66
128199	0.2446	52

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle tissue	UBERON:0002385	91.09	gold quality
hypothalamus	UBERON:0001898	82.48	gold quality
fundus of stomach	UBERON:0001160	74.56	gold quality
body of stomach	UBERON:0001161	74.31	gold quality
right hemisphere of cerebellum	UBERON:0014890	73.62	gold quality
stomach	UBERON:0000945	72.83	gold quality
cerebellum	UBERON:0002037	72.55	gold quality
cerebellar cortex	UBERON:0002129	72.50	gold quality
cerebellar hemisphere	UBERON:0002245	72.43	gold quality
substantia nigra	UBERON:0002038	64.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.27	gold quality
brain	UBERON:0000955	62.29	gold quality
cortical plate	UBERON:0005343	61.89	gold quality
multicellular organism	UBERON:0000468	61.65	gold quality
colonic epithelium	UBERON:0000397	60.47	silver quality
prostate gland	UBERON:0002367	59.00	gold quality
prefrontal cortex	UBERON:0000451	58.95	gold quality
nucleus accumbens	UBERON:0001882	58.27	gold quality
skin of leg	UBERON:0001511	56.00	gold quality
frontal cortex	UBERON:0001870	55.43	gold quality
monocyte	CL:0000576	55.41	gold quality
right frontal lobe	UBERON:0002810	55.33	gold quality
esophagus mucosa	UBERON:0002469	53.83	gold quality
right lobe of liver	UBERON:0001114	53.26	gold quality
adenohypophysis	UBERON:0002196	52.49	gold quality
blood	UBERON:0000178	52.21	gold quality
Brodmann (1909) area 9	UBERON:0013540	50.17	gold quality
tibial artery	UBERON:0007610	49.09	gold quality
cerebral cortex	UBERON:0000956	48.39	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	47.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.