LHX8

Summary

LHX8 (LIM homeobox 8, HGNC:28838) is a protein-coding gene on chromosome 1p31.1, encoding LIM/homeobox protein Lhx8 (Q68G74). Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants.

Source: NCBI Gene 431707 — RefSeq curated summary.

At a glance

• Gene–disease (curated): inherited primary ovarian failure (Limited, GenCC)
• Clinical variants (ClinVar): 53 total
• Transcription factor: yes — 12 downstream targets (CollecTRI)
• MANE Select transcript: NM_001256114

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28838
Approved symbol	LHX8
Name	LIM homeobox 8
Location	1p31.1
Locus type	gene with protein product
Status	Approved
Aliases	Lhx7
Ensembl gene	ENSG00000162624
Ensembl biotype	protein_coding
OMIM	604425
Entrez	431707

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 retained_intron

ENST00000294638, ENST00000356261, ENST00000607240, ENST00000696555, ENST00000929120, ENST00000929121

RefSeq mRNA: 2 — MANE Select: NM_001256114 NM_001001933, NM_001256114

CCDS: CCDS30756, CCDS58008

Canonical transcript exons

ENST00000356261 — 9 exons

Exon	Start	End
ENSE00001374729	75160819	75161533
ENSE00001604017	75148587	75148682
ENSE00001613974	75143845	75143948
ENSE00001741372	75156893	75157076
ENSE00001756505	75143118	75143338
ENSE00003468636	75136603	75136689
ENSE00003601674	75137100	75137261
ENSE00003623327	75140985	75141106
ENSE00003967689	75134388	75134954

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 96.56.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3290 / max 39.3260, expressed in 98 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
3527	0.1634	60
3526	0.0507	22
3529	0.0350	18
3530	0.0309	11
3531	0.0286	17
3528	0.0204	8

Top tissues by expression

228 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	96.56	gold quality
oocyte	CL:0000023	95.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.75	gold quality
buccal mucosa cell	CL:0002336	79.86	gold quality
oral cavity	UBERON:0000167	72.60	gold quality
minor salivary gland	UBERON:0001830	71.49	gold quality
mouth mucosa	UBERON:0003729	69.70	gold quality
saliva-secreting gland	UBERON:0001044	65.99	gold quality
caudate nucleus	UBERON:0001873	61.59	gold quality
putamen	UBERON:0001874	60.78	gold quality
lateral globus pallidus	UBERON:0002476	58.29	gold quality
lower lobe of lung	UBERON:0008949	57.60	silver quality
gall bladder	UBERON:0002110	56.70	gold quality
nucleus accumbens	UBERON:0001882	56.51	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	54.14	gold quality
tonsil	UBERON:0002372	53.54	gold quality
epithelium of nasopharynx	UBERON:0001951	53.45	gold quality
pharyngeal mucosa	UBERON:0000355	51.84	gold quality
gingiva	UBERON:0001828	49.35	silver quality
urinary bladder	UBERON:0001255	49.24	gold quality
globus pallidus	UBERON:0001875	46.33	silver quality
mucosa of paranasal sinus	UBERON:0005030	45.23	silver quality
esophagus mucosa	UBERON:0002469	45.20	gold quality
medial globus pallidus	UBERON:0002477	44.85	silver quality
middle temporal gyrus	UBERON:0002771	44.77	gold quality
testis	UBERON:0000473	44.34	gold quality
penis	UBERON:0000989	43.84	silver quality
left lobe of thyroid gland	UBERON:0001120	43.79	gold quality
thyroid gland	UBERON:0002046	43.61	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-93593	yes	1411.28
E-MTAB-8894	yes	491.19
E-ANND-3	no	2.91

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

12 targets.

Target	Regulation
AKT1
BDNF
BMP4	Activation
BRAF
DUSP1
GSC	Activation
IL2RA
LHX6	Activation
MSX1	Activation
MSX2	Activation
PKLR
SCNN1A

Upstream regulators (CollecTRI, top): CREB1, JUN, JUNB, JUND, SOHLH1

miRNA regulators (miRDB)

120 targeting LHX8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4803	99.98	71.99	3117
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-557	99.96	70.01	1640

Literature-anchored findings (GeneRIF, showing 10)

• Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis (PMID:16690745)
• Mutations in the LHX8 exons are uncommon in Caucasian women with premature ovarian failure. (PMID:17624344)
• LHX8 might play an important role in odontoma formation. This is 1st report on comparison of LHX8 expression between human odontoma-derived mesenchymal cells and normal adult dental mesenchymal stem cells and its overexpression in human samples. (PMID:21143530)
• Our tagging-single nucleotide polymorphism (tSNP)-based association analysis was negative for Tourette syndrome association with LHX8. (PMID:22435649)
• Increasing Lhx8 expression in neuronal cell lines also increased acetylcholine release. (PMID:24316404)
• Posttreatment monitoring by ASCL1/LHX8 methylation analysis in women with HIV treated for cervical intraepithelial neoplasia grade 2/3. (PMID:35152224)
• Heterozygous loss-of-function variants in LHX8 cause female infertility characterized by oocyte maturation arrest. (PMID:36029299)
• Validation of ASCL1 and LHX8 Methylation Analysis as Primary Cervical Cancer Screening Strategy in South African Women with Human Immunodeficiency Virus. (PMID:36366827)
• Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8. (PMID:36602025)
• LIM homeobox 8 reduced apoptosis and promoted periodontal tissue regeneration function of dental pulp stem cells. (PMID:38703583)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	lhx8a	ENSDARG00000002330
danio_rerio	lhx8b	ENSDARG00000042145
mus_musculus	Lhx8	ENSMUSG00000096225
rattus_norvegicus	Lhx8	ENSRNOG00000028348

Paralogs (20): FHL1 (ENSG00000022267), LMO3 (ENSG00000048540), LHX5 (ENSG00000089116), ZFHX4 (ENSG00000091656), LHX2 (ENSG00000106689), LHX6 (ENSG00000106852), LHX3 (ENSG00000107187), LHX4 (ENSG00000121454), LMO2 (ENSG00000135363), ZFHX2 (ENSG00000136367), LMX1B (ENSG00000136944), ZFHX3 (ENSG00000140836), LMO4 (ENSG00000143013), LHX9 (ENSG00000143355), CRIP3 (ENSG00000146215), LMX1A (ENSG00000162761), LMO1 (ENSG00000166407), CRIP2 (ENSG00000182809), CRIP1 (ENSG00000213145), LHX1 (ENSG00000273706)

Protein

Protein identifiers

LIM/homeobox protein Lhx8 — Q68G74 (reviewed: Q68G74)

All UniProt accessions (2): Q68G74, A0A8Q3WLD2

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Subcellular location. Nucleus.

Isoforms (2)

UniProt ID	Names	Canonical?
Q68G74-1	1	yes
Q68G74-2	2

RefSeq proteins (2): NP_001001933, NP_001243043* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR001781	Znf_LIM	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR050453	LIM_Homeobox_TF	Family

Pfam: PF00046, PF00412

UniProt features (8 total): domain 2, chain 1, DNA-binding region 1, region of interest 1, compositionally biased region 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q68G74-F1	69.46	0.38

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 110 (showing top): GOBP_FOREBRAIN_NEURON_DEVELOPMENT, GOBP_RESPONSE_TO_ETHANOL, BENPORATH_ES_WITH_H3K27ME3, GOBP_NEUROGENESIS, TACAATC_MIR508, GOBP_FOREBRAIN_DEVELOPMENT, GOBP_FOREBRAIN_GENERATION_OF_NEURONS, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1, GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, GOBP_HEAD_DEVELOPMENT, TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P, ACTTTAT_MIR1425P, GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT, GOBP_RESPONSE_TO_ALCOHOL

GO Biological Process (5): regulation of transcription by RNA polymerase II (GO:0006357), forebrain neuron development (GO:0021884), neuron differentiation (GO:0030182), response to ethanol (GO:0045471), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (7): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), metal ion binding (GO:0046872), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515), sequence-specific DNA binding (GO:0043565)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
forebrain neuron differentiation	1
central nervous system neuron development	1
cell differentiation	1
generation of neurons	1
response to alcohol	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
transcription cis-regulatory region binding	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
cation binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
DNA binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1530 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
LHX8	SOHLH1	Q5JUK2	962
LHX8	NOBOX	O60393	928
LHX8	FIGLA	Q6QHK4	918
LHX8	GBX1	Q14549	897
LHX8	MSX1	P28360	848
LHX8	YBX2	Q9Y2T7	845
LHX8	PAX9	P55771	795
LHX8	SATB2	Q9UPW6	686
LHX8	SOHLH2	Q9NX45	682
LHX8	DLX2	Q07687	679
LHX8	ZIC1	Q15915	671
LHX8	HOXC9	P31274	664
LHX8	HOXA2	O43364	647
LHX8	NKX2-1	P43699	647
LHX8	TMEM26	Q6ZUK4	629

IntAct

152 interactions, top by confidence:

A	B	Type	Score
LHX8	FIGLA	psi-mi:“MI:0915”(physical association)	0.700
PYGO1	BCL9	psi-mi:“MI:0914”(association)	0.700
LDB1	LHX8	psi-mi:“MI:0915”(physical association)	0.690
LHX8	LDB1	psi-mi:“MI:0915”(physical association)	0.690
LHX8	LDB1	psi-mi:“MI:0914”(association)	0.690
KLF3	LHX8	psi-mi:“MI:0915”(physical association)	0.560
LHX8	NUTM1	psi-mi:“MI:0915”(physical association)	0.560
LHX8	SCYL3	psi-mi:“MI:0915”(physical association)	0.560
LHX8	KLF3	psi-mi:“MI:0915”(physical association)	0.560
NUTM1	LHX8	psi-mi:“MI:0915”(physical association)	0.560
AXIN1	LHX8	psi-mi:“MI:0915”(physical association)	0.560
EFS	LHX8	psi-mi:“MI:0915”(physical association)	0.560
LHX8	LDB1	psi-mi:“MI:0915”(physical association)	0.560
ZBTB24	LHX8	psi-mi:“MI:0915”(physical association)	0.560
LDB2	LHX8	psi-mi:“MI:0915”(physical association)	0.560
LHX8	ATF6B	psi-mi:“MI:0915”(physical association)	0.560
FOXN1	LHX8	psi-mi:“MI:0915”(physical association)	0.560
CSNK2A1	LHX8	psi-mi:“MI:0915”(physical association)	0.560
LHX8	TBC1D1	psi-mi:“MI:0915”(physical association)	0.560
LHX8	GINS4	psi-mi:“MI:0915”(physical association)	0.560
NEDD9	LHX8	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (59): LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Affinity Capture-MS), LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Affinity Capture-MS), LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Two-hybrid), LHX8 (Two-hybrid)

ESM2 similar proteins: A0A8I6G705, A6QNT8, B5DFF2, D4A055, O00305, O14639, O16011, O19048, O95319, O95486, P56223, P60335, P60762, Q08DJ0, Q12800, Q13330, Q15365, Q15853, Q16514, Q3T174, Q4V860, Q5E9A3, Q5R8Y8, Q62599, Q63665, Q64705, Q68G74, Q6DH13, Q6NZH6, Q6P0B1, Q6ZRY4, Q792H5, Q7T2T1, Q7T2U9, Q86SE5, Q8K4B0, Q8K4G5, Q8K4Q0, Q8N122, Q8R0S4

Diamond homologs: A0JNI8, A2I8Z7, A2PZF9, G5EC36, G5EE86, O14639, O35652, O60663, O88609, O94929, O97581, P20154, P25791, P25800, P25801, P29673, P29674, P34764, P34765, P36198, P36200, P37137, P48742, P50211, P50212, P50458, P50480, P50481, P52889, P53405, P53406, P53407, P53408, P53409, P53410, P53411, P53412, P53413, P53667, P53668

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
SOHLH1	“up-regulates quantity by expression”	LHX8	“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	6
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1950 predictions. Top by Δscore:

Variant	Effect	Δscore
1:75140980:CACAG:C	acceptor_loss	1.0000
1:75140983:A:AG	acceptor_gain	1.0000
1:75140984:G:GA	acceptor_loss	1.0000
1:75140984:G:GG	acceptor_gain	1.0000
1:75140984:GGT:G	acceptor_gain	1.0000
1:75141104:CAGGT:C	donor_loss	1.0000
1:75141105:AGGT:A	donor_loss	1.0000
1:75141106:GGTA:G	donor_loss	1.0000
1:75141107:G:GA	donor_loss	1.0000
1:75141108:T:G	donor_loss	1.0000
1:75143326:G:GT	donor_gain	1.0000
1:75143843:AG:A	acceptor_gain	1.0000
1:75143843:AGG:A	acceptor_gain	1.0000
1:75143844:GG:G	acceptor_gain	1.0000
1:75143844:GGG:G	acceptor_gain	1.0000
1:75143844:GGGA:G	acceptor_gain	1.0000
1:75143844:GGGAA:G	acceptor_gain	1.0000
1:75143947:AGGT:A	donor_loss	1.0000
1:75143949:G:GG	donor_gain	1.0000
1:75143950:T:G	donor_loss	1.0000
1:75157072:GGATG:G	donor_gain	1.0000
1:75157073:GATG:G	donor_gain	1.0000
1:75157073:GATGG:G	donor_gain	1.0000
1:75157075:TGG:T	donor_loss	1.0000
1:75157076:GGTA:G	donor_loss	1.0000
1:75157077:G:GG	donor_gain	1.0000
1:75157077:GTA:G	donor_loss	1.0000
1:75157078:T:A	donor_loss	1.0000
1:75140981:A:AG	acceptor_gain	0.9900
1:75140983:AG:A	acceptor_gain	0.9900

AlphaMissense

2255 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:75137227:G:A	C78Y	1.000
1:75137254:T:C	L87P	1.000
1:75137257:T:C	L88P	1.000
1:75141000:T:A	W95R	1.000
1:75141000:T:C	W95R	1.000
1:75141005:T:A	H96Q	1.000
1:75141005:T:G	H96Q	1.000
1:75141012:T:A	C99S	1.000
1:75141012:T:C	C99R	1.000
1:75141013:G:C	C99S	1.000
1:75141014:T:G	C99W	1.000
1:75141016:T:A	L100H	1.000
1:75141016:T:C	L100P	1.000
1:75141021:T:A	C102S	1.000
1:75141021:T:C	C102R	1.000
1:75141022:G:A	C102Y	1.000
1:75141022:G:C	C102S	1.000
1:75141022:G:T	C102F	1.000
1:75141023:C:G	C102W	1.000
1:75141030:T:A	C105S	1.000
1:75141030:T:C	C105R	1.000
1:75141031:G:A	C105Y	1.000
1:75141031:G:C	C105S	1.000
1:75141031:G:T	C105F	1.000
1:75141032:C:G	C105W	1.000
1:75141060:T:C	C115R	1.000
1:75141061:G:A	C115Y	1.000
1:75141062:T:G	C115W	1.000
1:75141063:T:G	Y116D	1.000
1:75141087:T:A	C124S	1.000

dbSNP variants (sampled 300 via entrez): RS1000027947 (1:75145546 A>C,T), RS1000178763 (1:75138678 A>G), RS1000191102 (1:75129771 G>T), RS1000193912 (1:75182625 G>A,T), RS1000251056 (1:75138345 T>C), RS1000340813 (1:75146957 TCAA>T), RS1000372764 (1:75158481 G>A), RS1000373437 (1:75147194 G>A), RS1000381539 (1:75177581 C>A,T), RS1000428104 (1:75132657 C>G), RS1000440639 (1:75193863 T>G), RS1000443065 (1:75145133 G>A), RS1000475003 (1:75177410 C>T), RS1000506609 (1:75154098 T>C), RS1000558234 (1:75195024 A>C,G)

Disease associations

OMIM: gene MIM:604425 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
inherited primary ovarian failure	Limited	Autosomal dominant

Mondo (1): inherited primary ovarian failure (MONDO:0019852)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	5
trichostatin A	increases expression, affects cotreatment	3
entinostat	increases expression, affects cotreatment	2
belinostat	increases expression, affects cotreatment	2
Panobinostat	affects cotreatment, increases expression	2
Arsenic	affects methylation, increases methylation	2
Cyclosporine	increases expression, decreases methylation	2
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
propionaldehyde	decreases expression	1
arsenite	increases methylation	1
butyraldehyde	decreases expression	1
mercuric bromide	affects cotreatment, increases expression	1
pentanal	decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	decreases expression	1
Aldehydes	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	affects cotreatment, decreases expression	1
Tretinoin	increases expression	1
Triclosan	decreases expression	1
Aflatoxin B1	affects expression	1
Asbestos, Serpentine	decreases methylation	1
Asbestos, Crocidolite	decreases methylation	1
Asbestos, Amosite	decreases methylation	1
Okadaic Acid	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A3W5	SEES3-1V human LHX8, clone1	Embryonic stem cell	Male
CVCL_A3W6	SEES3-1V human LHX8, clone2	Embryonic stem cell	Male
CVCL_A3W7	SEES3-1V human LHX8, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.