LIF-AS2

Summary

LIF-AS2 (LIF antisense RNA 2, HGNC:28298) is a long non-coding RNA gene on chromosome 22q12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28298
Approved symbol	LIF-AS2
Name	LIF antisense RNA 2
Location	22q12.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	TP53LC08
Ensembl gene	ENSG00000268812
Ensembl biotype	lncRNA
Entrez	91370
RNAcentral	URS0000BC43CD — lncRNA, 812 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000608354

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000608354 — 1 exons

Exon	Start	End
ENSE00003705564	30246205	30246998

Expression profiles

Bgee: expression breadth ubiquitous, 136 present calls, max score 76.46.

FANTOM5 (CAGE): breadth broad, TPM avg 2.7280 / max 150.0521, expressed in 503 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191652	2.7280	503

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	76.46	gold quality
sural nerve	UBERON:0015488	71.47	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.32	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	64.09	gold quality
ganglionic eminence	UBERON:0004023	63.98	gold quality
mucosa of transverse colon	UBERON:0004991	61.87	gold quality
cortical plate	UBERON:0005343	60.94	gold quality
gall bladder	UBERON:0002110	60.63	gold quality
epithelium of nasopharynx	UBERON:0001951	60.20	gold quality
omental fat pad	UBERON:0010414	59.41	gold quality
peritoneum	UBERON:0002358	59.36	gold quality
transverse colon	UBERON:0001157	59.33	gold quality
metanephros cortex	UBERON:0010533	58.72	gold quality
adenohypophysis	UBERON:0002196	58.55	gold quality
adipose tissue of abdominal region	UBERON:0007808	58.31	gold quality
vermiform appendix	UBERON:0001154	58.22	gold quality
pericardium	UBERON:0002407	56.39	gold quality
right lobe of liver	UBERON:0001114	56.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	56.07	gold quality
islet of Langerhans	UBERON:0000006	55.71	gold quality
small intestine Peyer’s patch	UBERON:0003454	55.22	gold quality
left uterine tube	UBERON:0001303	55.08	gold quality
right atrium auricular region	UBERON:0006631	54.88	gold quality
small intestine	UBERON:0002108	54.41	gold quality
cardiac atrium	UBERON:0002081	54.33	gold quality
cortex of kidney	UBERON:0001225	54.11	gold quality
colon	UBERON:0001155	53.91	gold quality
upper lobe of left lung	UBERON:0008952	53.72	gold quality
caecum	UBERON:0001153	53.63	gold quality
intestine	UBERON:0000160	53.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.60

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.