LIFR-AS1

Summary

LIFR-AS1 (LIFR antisense RNA 1, HGNC:43600) is a long non-coding RNA gene on chromosome 5p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43600
Approved symbol	LIFR-AS1
Name	LIFR antisense RNA 1
Location	5p13.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000244968
Ensembl biotype	lncRNA
Entrez	100506495
RNAcentral	URS0000490DBB — lncRNA, 3803 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000500733, ENST00000500817, ENST00000514291, ENST00000652922, ENST00000657740, ENST00000658674, ENST00000660661, ENST00000661968, ENST00000666123, ENST00000669394, ENST00000670079, ENST00000670215, ENST00000671056, ENST00000671098, ENST00000788940

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500733 — 3 exons

Exon	Start	End
ENSE00001965894	38607600	38608862
ENSE00001984506	38556786	38559177
ENSE00001984922	38594922	38595069

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 78.43.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2675 / max 43.0608, expressed in 614 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
56191	1.0047	489
56192	0.2628	142

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	78.43	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.14	gold quality
calcaneal tendon	UBERON:0003701	77.35	gold quality
mucosa of stomach	UBERON:0001199	73.87	gold quality
popliteal artery	UBERON:0002250	73.68	gold quality
tibial artery	UBERON:0007610	73.68	gold quality
ventricular zone	UBERON:0003053	73.65	gold quality
ganglionic eminence	UBERON:0004023	73.53	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.89	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.60	silver quality
prefrontal cortex	UBERON:0000451	71.36	gold quality
aorta	UBERON:0000947	71.32	gold quality
hindlimb stylopod muscle	UBERON:0004252	71.22	gold quality
anterior cingulate cortex	UBERON:0009835	71.13	gold quality
left lobe of thyroid gland	UBERON:0001120	71.11	gold quality
nucleus accumbens	UBERON:0001882	70.95	gold quality
right lobe of thyroid gland	UBERON:0001119	70.94	gold quality
cortical plate	UBERON:0005343	70.89	gold quality
amygdala	UBERON:0001876	70.68	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.61	gold quality
descending thoracic aorta	UBERON:0002345	70.58	gold quality
right uterine tube	UBERON:0001302	70.46	gold quality
muscle of leg	UBERON:0001383	70.35	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.31	gold quality
hypothalamus	UBERON:0001898	70.24	gold quality
caudate nucleus	UBERON:0001873	70.21	gold quality
putamen	UBERON:0001874	70.16	gold quality
cerebellar hemisphere	UBERON:0002245	70.16	gold quality
right frontal lobe	UBERON:0002810	70.14	gold quality
left ovary	UBERON:0002119	70.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• LIFR-AS1 serves as a competitive endogenous RNA for miR-29a to inhibit its expression and up-regulate downstream target TNFAIP3 expression, finally modulating the resistance of colorectal cancer to pohotodynamic therapy. (PMID:29807108)
• High long non-coding LIFR-AS1 expression correlates with poor survival in gastric carcinoma. (PMID:32495872)
• Long noncoding RNA LIFR-AS1 suppresses proliferation, migration and invasion and promotes apoptosis through modulating miR-4262/NF-kappaB pathway in glioma. (PMID:33070767)
• lncRNA LIFRAS1 inhibits gastric carcinoma cell proliferation, migration and invasion by sponging miR4698. (PMID:33355363)
• M(6)A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling. (PMID:34658294)
• Long non-coding RNA LIFR-AS1 suppressed the proliferation, angiogenesis, migration and invasion of papillary thyroid cancer cells via the miR-31-5p/SIDT2 axis. (PMID:34781815)
• Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers. (PMID:35071590)
• LncRNA LIFR-AS1 overexpression suppressed the progression of serous ovarian carcinoma. (PMID:35778954)
• Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer. (PMID:36316703)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.