LIN28B-AS1

Summary

LIN28B-AS1 (LIN28B antisense RNA 1, HGNC:21553) is a long non-coding RNA gene on chromosome 6q16.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21553
Approved symbol	LIN28B-AS1
Name	LIN28B antisense RNA 1
Location	6q16.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	dJ439I14.1
Ensembl gene	ENSG00000203809
Ensembl biotype	lncRNA
Entrez	100113403
RNAcentral	URS0000191873 — lncRNA, 575 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000369123, ENST00000636060, ENST00000636682, ENST00000636951, ENST00000637414, ENST00000659952, ENST00000668527, ENST00000835621, ENST00000835622, ENST00000835623, ENST00000835624, ENST00000835625, ENST00000835626, ENST00000835627

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000369123 — 3 exons

Exon	Start	End
ENSE00001448854	104940178	104940213
ENSE00001448855	104940378	104940527
ENSE00002546738	104936294	104936682

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 98.94.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0631 / max 6.4883, expressed in 36 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
74864	0.0631	36

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	98.94	silver quality
thymus	UBERON:0002370	97.69	silver quality
cerebellar vermis	UBERON:0004720	85.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.72	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.10	silver quality
muscle tissue	UBERON:0002385	72.38	gold quality
quadriceps femoris	UBERON:0001377	70.57	gold quality
skeletal muscle tissue	UBERON:0001134	69.99	gold quality
testis	UBERON:0000473	68.92	gold quality
ganglionic eminence	UBERON:0004023	68.83	gold quality
left testis	UBERON:0004533	68.50	gold quality
right testis	UBERON:0004534	67.44	gold quality
cortical plate	UBERON:0005343	66.39	gold quality
putamen	UBERON:0001874	64.53	gold quality
prefrontal cortex	UBERON:0000451	64.16	gold quality
sural nerve	UBERON:0015488	64.00	silver quality
superior frontal gyrus	UBERON:0002661	63.68	gold quality
caudate nucleus	UBERON:0001873	63.19	gold quality
frontal cortex	UBERON:0001870	62.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.17	gold quality
placenta	UBERON:0001987	61.80	gold quality
primary visual cortex	UBERON:0002436	61.79	gold quality
cerebral cortex	UBERON:0000956	61.64	gold quality
right frontal lobe	UBERON:0002810	61.29	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.27	gold quality
anterior cingulate cortex	UBERON:0009835	60.58	gold quality
amygdala	UBERON:0001876	59.50	gold quality
temporal lobe	UBERON:0001871	59.49	gold quality
brain	UBERON:0000955	58.98	gold quality
Ammon’s horn	UBERON:0001954	58.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Study provides evidence that LIN28B-AS1 was the first functional cancer-testis (CT)-lncRNA in cancer and comprises a regulation network with CT protein IGF2BP1 and LIN28B in the carcinogenesis of lung adenocarcinoma (LUAD). LIN28B-AS1 regulates LIN28B expression and promotes proliferation and metastasis in LUAD cells by interacting with IGF2BP1. (PMID:30353165)
• LIN28B-AS1-IGF2BP1 binding promotes hepatocellular carcinoma cell progression. (PMID:32917856)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.