LINC-ADAIN

Summary

LINC-ADAIN (long intergenic non-coding adipose anti-inflammatory, HGNC:49686) is a long non-coding RNA gene on chromosome 9p24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49686
Approved symbol	LINC-ADAIN
Name	long intergenic non-coding adipose anti-inflammatory
Location	9p24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-DMRT2, lnc-DRMT2, TCONS_00015639
Ensembl gene	ENSG00000281769
Ensembl biotype	lncRNA
Entrez	102800446
RNAcentral	URS000075B229 — lncRNA, 499 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000625222, ENST00000778964, ENST00000778965

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000625222 — 1 exons

Exon	Start	End
ENSE00003765753	1045625	1048641

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 75.76.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1156 / max 54.1667, expressed in 18 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95818	0.1156	18

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortex of kidney	UBERON:0001225	75.76	gold quality
metanephros cortex	UBERON:0010533	72.73	gold quality
kidney	UBERON:0002113	71.84	gold quality
adult mammalian kidney	UBERON:0000082	70.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.88	gold quality
thymus	UBERON:0002370	67.11	silver quality
hindlimb stylopod muscle	UBERON:0004252	66.61	gold quality
quadriceps femoris	UBERON:0001377	65.49	gold quality
cerebellar vermis	UBERON:0004720	64.61	gold quality
adipose tissue	UBERON:0001013	64.20	gold quality
anterior cingulate cortex	UBERON:0009835	63.76	gold quality
thoracic mammary gland	UBERON:0005200	63.66	gold quality
bone marrow	UBERON:0002371	61.71	silver quality
spleen	UBERON:0002106	59.38	silver quality
liver	UBERON:0002107	57.00	gold quality
omental fat pad	UBERON:0010414	56.56	gold quality
apex of heart	UBERON:0002098	54.24	gold quality
calcaneal tendon	UBERON:0003701	54.02	silver quality
skeletal muscle tissue	UBERON:0001134	53.83	silver quality
multicellular organism	UBERON:0000468	53.00	gold quality
prefrontal cortex	UBERON:0000451	52.70	silver quality
urinary bladder	UBERON:0001255	50.72	gold quality
lymph node	UBERON:0000029	50.40	silver quality
muscle of leg	UBERON:0001383	49.45	gold quality
frontal cortex	UBERON:0001870	49.05	silver quality
tibial nerve	UBERON:0001323	48.69	gold quality
descending thoracic aorta	UBERON:0002345	48.46	gold quality
gastrocnemius	UBERON:0001388	48.39	gold quality
placenta	UBERON:0001987	48.23	gold quality
left uterine tube	UBERON:0001303	48.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• These results conclude linc01230 as a novel modifier in PPARgamma-mediated activation of Akt in endothelial function. (PMID:30454889)
• linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability. (PMID:38753486)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.