LINC-ROR

Summary

LINC-ROR (long intergenic non-protein coding RNA, regulator of reprogramming, HGNC:43773) is a long non-coding RNA gene on chromosome 18q21.31.

This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis.

Source: NCBI Gene 100885779 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43773
Approved symbol	LINC-ROR
Name	long intergenic non-protein coding RNA, regulator of reprogramming
Location	18q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	lincRNA-RoR, lincRNA-ST8SIA3, ROR
Ensembl gene	ENSG00000258609
Ensembl biotype	lncRNA
OMIM	615173
Entrez	100885779
RNAcentral	URS00007681C7 — lncRNA, 2603 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000553704, ENST00000642403, ENST00000643706, ENST00000644118, ENST00000644575, ENST00000644805, ENST00000645956, ENST00000646314, ENST00000739927

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553704 — 4 exons

Exon	Start	End
ENSE00002436002	57069810	57070003
ENSE00002457895	57054558	57056250
ENSE00002471664	57071904	57072119
ENSE00002528839	57057500	57058000

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 79.50.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	79.50	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.87	gold quality
monocyte	CL:0000576	72.76	gold quality
sural nerve	UBERON:0015488	71.73	gold quality
leukocyte	CL:0000738	71.67	gold quality
colonic epithelium	UBERON:0000397	67.25	silver quality
cortical plate	UBERON:0005343	66.48	gold quality
bone marrow	UBERON:0002371	64.24	gold quality
ganglionic eminence	UBERON:0004023	64.24	gold quality
blood	UBERON:0000178	61.04	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.71	gold quality
calcaneal tendon	UBERON:0003701	54.89	gold quality
liver	UBERON:0002107	53.03	gold quality
stromal cell of endometrium	CL:0002255	52.69	silver quality
superior frontal gyrus	UBERON:0002661	52.44	gold quality
lymph node	UBERON:0000029	52.35	gold quality
granulocyte	CL:0000094	52.32	gold quality
cortex of kidney	UBERON:0001225	52.01	gold quality
vermiform appendix	UBERON:0001154	51.25	gold quality
endometrium	UBERON:0001295	50.96	gold quality
prefrontal cortex	UBERON:0000451	50.59	gold quality
right uterine tube	UBERON:0001302	50.21	gold quality
kidney	UBERON:0002113	50.06	gold quality
right lobe of liver	UBERON:0001114	49.88	silver quality
adult mammalian kidney	UBERON:0000082	49.46	gold quality
muscle of leg	UBERON:0001383	49.30	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	49.27	gold quality
islet of Langerhans	UBERON:0000006	49.07	gold quality
pancreas	UBERON:0001264	48.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.73

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Linc-RoR expression is positively correlated with the undifferentiated embryonic stem cell state. (PMID:23541921)
• Linc-RoR is a ceRNA and acts as a miR-145 “sponge” to inhibit mediation of the differentiation of ETs by miR-145. These results suggest that linc-RoR has an important role during endometrial carcinogenesis. (PMID:24589415)
• results indicate that linc-ROR functions as an important regulator of EMT and can promote breast cancer progression and metastasis through regulation of miRNAs. (PMID:24922071)
• Results show that lincRNA-RoR is overexpressed in triple-negative breast cancer (TNBC) and metastasis and may function as a competitive endogenous RNA sponge in TNBC. (PMID:25253741)
• The results reveal a novel mechanism by which ROR may serve as a decoy oncoRNA that blocks binding surfaces, preventing the recruitment of histone modifying enzymes, thereby specifying a new pattern of histone modifications that promote tumorigenesis. (PMID:26169368)
• Data show that long intergenic non-protein coding RNA ROR may act as a competitive endogenous RNAs (ceRNAs), effectively becoming a sink for microRBA miR-145, thereby activating the derepression of core transcription factors Nanog. (PMID:26636540)
• results support a role for Linc-RoR in c-Myc expression in part by specifically enhancing its mRNA stability, leading to cell proliferation and tumorigenesis. (PMID:26656491)
• Our study demonstrated that linc-ROR is an important marker for multidrug resistance of breast cancer, and its up-regulation is important for chemotherapy tolerance and invasion of breast cancer (PMID:26883251)
• Results indicate that linc-ROR acts as an important regulator of ZEB1, can promote invasion and metastasis in pancreatic cancer. (PMID:26898939)
• We identified an association between polymorphisms in a long intergenic non-coding RNA (lincRNA) gene (AC011288.2) and pneumococcal bacteremia and replicated the results in the same population (PMID:27236921)
• our study proved that lncRNA-ROR was highly associated with the proliferation, metastasis and apoptosis of NPC. The enrichment of lncRNA-ROR played a critucal functional role in chemoresistance. (PMID:27311700)
• lncRNA-ROR effectively maintains Sox2 gene expression through competitive binding to miR-145. (PMID:27346547)
• Data suggest that long non-coding RNA RoR (LncRNA-ROR) might act as a marker of prognosis and therapeutic target for gallbladder cancer. (PMID:27449039)
• Data show that long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) suppresses gemcitabine (Gem)-induced autophagy and apoptosis in breast cancer cells by silencing miR-34a expression. (PMID:27449099)
• Overexpression of lncRNA ROR is associated with gastric cancer. (PMID:27602437)
• LincRNA-ROR decreases sensitivity to radiotherapy via the negative regulation of p53/miR-145 and may represent a potential target for the treatment of CRC. (PMID:27696511)
• the characteristics of linc-ROR and their roles in different types of human cancers, are reviewed. (PMID:27855392)
• Authors revealed that lncRNA-ROR expression level was obviously elevated in CRC tissues. Also, lncRNA-ROR knockdown suppressed cell growth and lncRNA-ROR has a tumor-promoting effect on Colorectal Cancer progression and proliferation in vitro and in vivo, and that lncRNA-ROR can partially suppress the p53 pathway. (PMID:28216611)
• the inhibited expression of linc-ROR could not only increase sensitivity to docetaxel and reverse EMT process, but also reduce the capacity of proliferation, migration and invasion in docetaxel-resistant LAD cells. (PMID:28388536)
• Through a stratification analysis, 5q11.2/MAP3K1 (rs16886034, rs16886364, rs16886397, rs1017226, rs16886448) and 7q32.3/LINC-PINT (rs4593472) were associated with Luminal A, and 10q26.1/FGFR2 (rs35054928) was associated with Luminal B. (PMID:28408616)
• this study demonstrated the association of linc-RoR overexpression in undifferentiated oral tumors and its prognostic value to predict the therapeutic response. (PMID:28443494)
• Increased lncRNA ROR expression significantly promoted tumor cells proliferation, inhibited cells apoptosis, facilitated cells metastasis and contributed to the formation of epithelial-to-mesenchymal phenotype. (PMID:28463831)
• total of 775 lncRNAs (325 up-regulated and 450 down-regulated) and 935 mRNAs (329 up-regulated and 606 down-regulated) were differentially expressed in HLE B-3 cells during TGF-beta2-induced EMT compared to normal HLE B-3 cells. (PMID:28511643)
• These results indicate that inhibition of long non-coding RNA ROR reverses resistance to Tamoxifen by inducing autophagy in breast cancer. (PMID:28635401)
• we constructed pterygium-related lncRNA libraries by using microarray to investigate the potential roles of lncRNAs in pterygium. In this study, our objective was to explore the role of mRNA in pterygium (PMID:28664906)
• we demonstrated for the first time that the levels of linc-ROR expression were significantly upregulated in both breast cancer tissues and plasma, and the increased levels of linc-ROR were associated with ER, PR, and lymph node metastasis. (PMID:28869448)
• lncRNA ROR was expressed at high levels in RCC tissues, and its expression was negatively correlated with the survival rates of patients with RCC. (PMID:29039528)
• High-resolution transcriptomics identified lincRNAs that form part of the coordinated response during macrophage activation, including specific macrophage lincRNAs associated with human cardiometabolic disorders that modulate macrophage inflammatory functions (PMID:29133519)
• Our results demonstrate that the linc-ROR-miRNA-SOX9 regulatory network may represent a novel therapeutic target for esophageal squamous cell carcinoma (PMID:29237490)
• results indicate that ROR, PVT1, and HOTAIR have important regulatory roles during the development of papillary thyroid carcinomas (PMID:29280051)
• A significant increase was observed in expression of STAT3 and lnc-DC genes but not SOCS1 in coronary artery disease + versus coronary artery disease- patients. (PMID:29398326)
• Data found rs4801078 TT genotype in Linc-ROR had a significant association with higher risk of breast caBC. The expression of Linc-ROR mRNA was closely related with the alleles of rs4801078 and with the number of pregnancy and menopausal status. (PMID:29549263)
• Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression (PMID:29559320)
• MUC1 was a potential molecular target may help explain the role of lincRNA-ROR/miR-145 for invasion and metastasis in Triple-negative breast cancer cell lines. (PMID:29673594)
• Linc-ROR is highly expressed in the ectopic endometrium of adenomyosis, and it can promote the proliferative activity of endometrial cells by activating the PI3K-Akt pathway. (PMID:29762822)
• High lncRNA ROR expression was associated with worse prognosis in cancers. [meta-analysis] (PMID:30076198)
• High LINC-ROR expression is associated with glioblastoma. (PMID:30852975)
• Our experiments indicated the HepG2 cells could transfer its Linc-ROR to the LO2 cells via exosomes, then influenced the recipient cells (PMID:31400406)
• Linc-RoR promotes proliferation, migration, and invasion via the Hippo/YAP pathway in pancreatic cancer cells. (PMID:31452251)
• Long non-coding RNA ROR regulated ABCB1 to induce cisplatin resistance in osteosarcoma by sponging miR-153-3p. (PMID:31539112)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.