LINC00114

Summary

LINC00114 (long intergenic non-protein coding RNA 114, HGNC:1265) is a long non-coding RNA gene on chromosome 21q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1265
Approved symbol	LINC00114
Name	long intergenic non-protein coding RNA 114
Location	21q22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223806
Ensembl biotype	lncRNA
OMIM	611723
Entrez	400866
RNAcentral	URS000009D511 — lncRNA, 1790 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000411989, ENST00000429621, ENST00000448579, ENST00000663481, ENST00000785532, ENST00000785533, ENST00000785534, ENST00000785535, ENST00000785536, ENST00000785537, ENST00000785538, ENST00000785539, ENST00000785540, ENST00000785541, ENST00000785542, ENST00000785543

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411989 — 4 exons

Exon	Start	End
ENSE00001610560	38739021	38739329
ENSE00001640534	38741321	38742517
ENSE00001660742	38740884	38741068
ENSE00001738568	38740316	38740414

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 80.23.

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.23	gold quality
sural nerve	UBERON:0015488	67.52	silver quality
mucosa of transverse colon	UBERON:0004991	63.96	gold quality
ganglionic eminence	UBERON:0004023	59.76	gold quality
cortical plate	UBERON:0005343	57.97	gold quality
rectum	UBERON:0001052	57.76	gold quality
calcaneal tendon	UBERON:0003701	57.08	gold quality
transverse colon	UBERON:0001157	56.16	gold quality
bone marrow	UBERON:0002371	56.05	gold quality
duodenum	UBERON:0002114	54.76	gold quality
monocyte	CL:0000576	54.25	silver quality
descending thoracic aorta	UBERON:0002345	54.01	gold quality
small intestine	UBERON:0002108	53.37	gold quality
intestine	UBERON:0000160	53.04	gold quality
thoracic aorta	UBERON:0001515	52.89	gold quality
colon	UBERON:0001155	52.84	gold quality
small intestine Peyer’s patch	UBERON:0003454	52.83	gold quality
lymph node	UBERON:0000029	52.68	gold quality
ascending aorta	UBERON:0001496	52.60	gold quality
vermiform appendix	UBERON:0001154	52.30	gold quality
stromal cell of endometrium	CL:0002255	52.23	silver quality
endocervix	UBERON:0000458	52.00	gold quality
tibial artery	UBERON:0007610	51.68	gold quality
popliteal artery	UBERON:0002250	51.66	gold quality
gall bladder	UBERON:0002110	51.42	gold quality
prefrontal cortex	UBERON:0000451	50.66	silver quality
superior frontal gyrus	UBERON:0002661	50.61	gold quality
blood	UBERON:0000178	50.51	silver quality
right coronary artery	UBERON:0001625	50.07	gold quality
smooth muscle tissue	UBERON:0001135	50.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LINC00114 promoted nasopharyngeal carcinoma progression and radioresistance in vitro and in vivo through regulating ERK/JNK signaling pathway via targeting miR-203. (PMID:32196600)
• Identification of the 3-lncRNA Signature as a Prognostic Biomarker for Colorectal Cancer. (PMID:33302562)
• LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1. (PMID:35414117)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.