LINC00115

Summary

LINC00115 (long intergenic non-protein coding RNA 115, HGNC:26211) is a long non-coding RNA gene on chromosome 1p36.33.

Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing; negative regulation of miRNA-mediated gene silencing; and positive regulation of canonical Wnt signaling pathway.

Source: NCBI Gene 79854 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26211
Approved symbol	LINC00115
Name	long intergenic non-protein coding RNA 115
Location	1p36.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ22639
Ensembl gene	ENSG00000225880
Ensembl biotype	lncRNA
Entrez	79854
RNAcentral	URS0002A18F21 — lncRNA, 6494 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 92 — 92 lncRNA

ENST00000414688, ENST00000419394, ENST00000440200, ENST00000441245, ENST00000447500, ENST00000447954, ENST00000473798, ENST00000506640, ENST00000634337, ENST00000635509, ENST00000648019, ENST00000692781, ENST00000743821, ENST00000743822, ENST00000743823, ENST00000743824, ENST00000743825, ENST00000743826, ENST00000743827, ENST00000743828, ENST00000743829, ENST00000743830, ENST00000743831, ENST00000743832, ENST00000743833, ENST00000743834, ENST00000743835, ENST00000743836, ENST00000743837, ENST00000743838, ENST00000743839, ENST00000743840, ENST00000743841, ENST00000743842, ENST00000743843, ENST00000743844, ENST00000743845, ENST00000743846, ENST00000743847, ENST00000743848, ENST00000743849, ENST00000743850, ENST00000743851, ENST00000743852, ENST00000743853, ENST00000743854, ENST00000743855, ENST00000743856, ENST00000743857, ENST00000743858, ENST00000743859, ENST00000743860, ENST00000743861, ENST00000743862, ENST00000743863, ENST00000743864, ENST00000743865, ENST00000743866, ENST00000743867, ENST00000743868, ENST00000743869, ENST00000743870, ENST00000743871, ENST00000743872, ENST00000743873, ENST00000743874, ENST00000743875, ENST00000743876, ENST00000743877, ENST00000743878, ENST00000744077, ENST00000744078, ENST00000744079, ENST00000744080, ENST00000744081, ENST00000744082, ENST00000744083, ENST00000744084, ENST00000744085, ENST00000744086, ENST00000744087, ENST00000745227, ENST00000745228, ENST00000745229, ENST00000745539, ENST00000745540, ENST00000745541, ENST00000745542, ENST00000745543, ENST00000745544, ENST00000745545, ENST00000745546

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414688 — 3 exons

Exon	Start	End
ENSE00001745637	720032	720200
ENSE00003812502	732017	732212
ENSE00003814134	711867	711922

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 78.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.7223 / max 31.0851, expressed in 1197 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9665	2.7223	1197

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	78.91	gold quality
lower esophagus mucosa	UBERON:0035834	75.65	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.45	gold quality
left ovary	UBERON:0002119	75.21	gold quality
cerebellar hemisphere	UBERON:0002245	75.19	gold quality
cerebellum	UBERON:0002037	75.16	gold quality
cerebellar cortex	UBERON:0002129	75.11	gold quality
prostate gland	UBERON:0002367	75.10	gold quality
right ovary	UBERON:0002118	75.00	gold quality
right uterine tube	UBERON:0001302	74.95	gold quality
popliteal artery	UBERON:0002250	74.73	gold quality
tibial artery	UBERON:0007610	74.69	gold quality
ovary	UBERON:0000992	74.17	gold quality
tibial nerve	UBERON:0001323	74.17	gold quality
endocervix	UBERON:0000458	74.12	gold quality
vagina	UBERON:0000996	73.79	gold quality
ectocervix	UBERON:0012249	73.34	gold quality
right coronary artery	UBERON:0001625	73.27	gold quality
uterine cervix	UBERON:0000002	73.15	gold quality
body of uterus	UBERON:0009853	73.13	gold quality
pituitary gland	UBERON:0000007	72.97	gold quality
right lobe of liver	UBERON:0001114	72.90	gold quality
myometrium	UBERON:0001296	72.62	gold quality
mucosa of transverse colon	UBERON:0004991	72.49	gold quality
adenohypophysis	UBERON:0002196	72.38	gold quality
ascending aorta	UBERON:0001496	71.93	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.63	gold quality
thoracic aorta	UBERON:0001515	71.54	gold quality
left lobe of thyroid gland	UBERON:0001120	71.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR-7. (PMID:32175684)
• Down-regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR-212-5p/FZD5/Wnt/beta-catenin axis. (PMID:34697900)
• Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2). (PMID:35184643)
• Long intergenic non-protein coding RNA 115 (Linc00115): A notable oncogene in human malignancies. (PMID:38070791)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.