LINC00158

Summary

LINC00158 (long intergenic non-protein coding RNA 158, HGNC:1283) is a long non-coding RNA gene on chromosome 21q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1283
Approved symbol	LINC00158
Name	long intergenic non-protein coding RNA 158
Location	21q21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000185433
Ensembl biotype	lncRNA
Entrez	54072
RNAcentral	URS000075EB51 — lncRNA, 1480 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 27 lncRNA

ENST00000332587, ENST00000439840, ENST00000440205, ENST00000441013, ENST00000652840, ENST00000653079, ENST00000655536, ENST00000657301, ENST00000659435, ENST00000659593, ENST00000659748, ENST00000662287, ENST00000662610, ENST00000662734, ENST00000662827, ENST00000664370, ENST00000665160, ENST00000665829, ENST00000667265, ENST00000668015, ENST00000668944, ENST00000669436, ENST00000670098, ENST00000671034, ENST00000686572, ENST00000843938, ENST00000843939

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000332587 — 5 exons

Exon	Start	End
ENSE00001299512	25431178	25431701
ENSE00001312769	25429766	25430009
ENSE00001543401	25385820	25386338
ENSE00001543403	25420708	25420800
ENSE00001543404	25424554	25424649

Expression profiles

Bgee: expression breadth ubiquitous, 142 present calls, max score 88.65.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7779 / max 182.6972, expressed in 95 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189921	0.1672	54
189923	0.1611	56
189925	0.1344	42
189928	0.0918	12
189924	0.0678	32
189922	0.0473	28
189927	0.0430	9
189920	0.0425	21
189926	0.0227	12

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.65	gold quality
sperm	CL:0000019	87.67	gold quality
buccal mucosa cell	CL:0002336	83.61	silver quality
colonic epithelium	UBERON:0000397	79.62	gold quality
left testis	UBERON:0004533	78.16	gold quality
right testis	UBERON:0004534	77.52	gold quality
testis	UBERON:0000473	76.21	gold quality
sural nerve	UBERON:0015488	68.10	gold quality
cerebellar hemisphere	UBERON:0002245	67.66	gold quality
cerebellar cortex	UBERON:0002129	67.53	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.07	gold quality
cerebellum	UBERON:0002037	65.47	gold quality
nucleus accumbens	UBERON:0001882	64.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.34	gold quality
right frontal lobe	UBERON:0002810	64.11	gold quality
pancreatic ductal cell	CL:0002079	64.07	silver quality
caudate nucleus	UBERON:0001873	63.08	gold quality
ventricular zone	UBERON:0003053	63.07	gold quality
anterior cingulate cortex	UBERON:0009835	62.44	gold quality
putamen	UBERON:0001874	62.35	gold quality
calcaneal tendon	UBERON:0003701	61.43	gold quality
ganglionic eminence	UBERON:0004023	61.34	gold quality
prefrontal cortex	UBERON:0000451	60.70	gold quality
hypothalamus	UBERON:0001898	60.28	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.74	gold quality
amygdala	UBERON:0001876	59.70	gold quality
vermiform appendix	UBERON:0001154	58.90	gold quality
neocortex	UBERON:0001950	58.69	gold quality
lymph node	UBERON:0000029	58.21	gold quality
adult organism	UBERON:0007023	58.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.