LINC00160

Summary

LINC00160 (long intergenic non-protein coding RNA 160, HGNC:1294) is a long non-coding RNA gene on chromosome 21q22.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1294
Approved symbol	LINC00160
Name	long intergenic non-protein coding RNA 160
Location	21q22.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230978
Ensembl biotype	lncRNA
Entrez	54064
RNAcentral	URS000075C4D7 — lncRNA, 694 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000430635, ENST00000651753, ENST00000846375, ENST00000846376

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430635 — 6 exons

Exon	Start	End
ENSE00001601444	34734686	34734756
ENSE00001697304	34733961	34734041
ENSE00001721912	34724046	34724196
ENSE00001743703	34732909	34733079
ENSE00004274111	34737110	34737202
ENSE00004274112	34723807	34723953

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 69.14.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ectocervix	UBERON:0012249	69.14	gold quality
skeletal muscle tissue	UBERON:0001134	66.39	gold quality
left ovary	UBERON:0002119	65.11	gold quality
minor salivary gland	UBERON:0001830	64.60	gold quality
saliva-secreting gland	UBERON:0001044	63.96	gold quality
gastrocnemius	UBERON:0001388	62.10	gold quality
tonsil	UBERON:0002372	62.10	gold quality
muscle of leg	UBERON:0001383	61.84	gold quality
vagina	UBERON:0000996	61.54	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.92	gold quality
myometrium	UBERON:0001296	57.76	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.13	gold quality
placenta	UBERON:0001987	54.60	gold quality
liver	UBERON:0002107	52.42	gold quality
lymph node	UBERON:0000029	51.45	gold quality
multicellular organism	UBERON:0000468	51.22	gold quality
thoracic mammary gland	UBERON:0005200	51.00	gold quality
thyroid gland	UBERON:0002046	50.89	gold quality
prostate gland	UBERON:0002367	50.62	gold quality
monocyte	CL:0000576	50.42	silver quality
lower esophagus muscularis layer	UBERON:0035833	50.30	gold quality
esophagus	UBERON:0001043	50.02	gold quality
esophagus mucosa	UBERON:0002469	49.93	gold quality
islet of Langerhans	UBERON:0000006	49.87	gold quality
blood	UBERON:0000178	48.78	silver quality
subcutaneous adipose tissue	UBERON:0002190	46.72	gold quality
anterior cingulate cortex	UBERON:0009835	46.57	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	46.55	gold quality
cortex of kidney	UBERON:0001225	45.62	silver quality
adrenal gland	UBERON:0002369	44.95	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC00160 mediated paclitaxel-And doxorubicin-resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPbeta. (PMID:32652877)
• STAT3-regulated LncRNA LINC00160 mediates cell proliferation and cell metabolism of prostate cancer cells by repressing RCAN1 expression. (PMID:35067783)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.