LINC00161

Summary

LINC00161 (long intergenic non-protein coding RNA 161, HGNC:17138) is a long non-coding RNA gene on chromosome 21q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17138
Approved symbol	LINC00161
Name	long intergenic non-protein coding RNA 161
Location	21q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	HORAS5
Ensembl gene	ENSG00000226935
Ensembl biotype	lncRNA
Entrez	118421
RNAcentral	URS0000017EC0 — lncRNA, 870 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000412526, ENST00000455939, ENST00000825125

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412526 — 2 exons

Exon	Start	End
ENSE00001621285	28539318	28539884
ENSE00001680619	28540053	28540355

Expression profiles

Bgee: expression breadth ubiquitous, 146 present calls, max score 85.50.

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.50	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.73	gold quality
colonic epithelium	UBERON:0000397	75.19	gold quality
buccal mucosa cell	CL:0002336	70.48	silver quality
sperm	CL:0000019	64.91	gold quality
ganglionic eminence	UBERON:0004023	64.78	gold quality
corpus callosum	UBERON:0002336	64.76	gold quality
prostate gland	UBERON:0002367	62.60	gold quality
mucosa of paranasal sinus	UBERON:0005030	62.49	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	61.70	gold quality
secondary oocyte	CL:0000655	61.66	gold quality
lower lobe of lung	UBERON:0008949	61.52	silver quality
cortical plate	UBERON:0005343	61.38	gold quality
cerebellar vermis	UBERON:0004720	61.20	gold quality
pericardium	UBERON:0002407	60.95	gold quality
stromal cell of endometrium	CL:0002255	60.74	gold quality
saphenous vein	UBERON:0007318	60.13	gold quality
thymus	UBERON:0002370	59.72	gold quality
inferior vagus X ganglion	UBERON:0005363	59.71	gold quality
trigeminal ganglion	UBERON:0001675	59.62	gold quality
nipple	UBERON:0002030	59.53	gold quality
germinal epithelium of ovary	UBERON:0001304	59.52	gold quality
pharyngeal mucosa	UBERON:0000355	59.50	gold quality
oocyte	CL:0000023	59.47	gold quality
pons	UBERON:0000988	59.46	gold quality
subthalamic nucleus	UBERON:0001906	59.43	gold quality
ventral tegmental area	UBERON:0002691	59.33	gold quality
trachea	UBERON:0003126	59.31	gold quality
cardia of stomach	UBERON:0001162	59.30	gold quality
synovial joint	UBERON:0002217	59.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• LINC00161 is an essential regulator in cisplatin-induced apoptosis, and the LINC00161-miR-645-IFIT2 signalling axis plays an important role in reducing osteosarcoma chemoresistance. (PMID:27609068)
• Linc-USP16 suppressed AKT pathway activation via regulation of PTEN expression in a transcription-independent manner. (PMID:29179215)
• High LINC00161 expression is associated with drug resistance in ovarian cancer. (PMID:30556928)
• LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism. (PMID:32618200)
• Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma. (PMID:33414518)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.