LINC00163

Summary

LINC00163 (long intergenic non-protein coding RNA 163, HGNC:33165) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33165
Approved symbol	LINC00163
Name	long intergenic non-protein coding RNA 163
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	NLC1-A, NLC1A
Ensembl gene	ENSG00000234880
Ensembl biotype	lncRNA
OMIM	610259
Entrez	727699
RNAcentral	URS00001D6B47 — lncRNA, 2155 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000434081, ENST00000439088

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434081 — 2 exons

Exon	Start	End
ENSE00001609589	44989864	44991835
ENSE00001707883	44993904	44994086

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 75.46.

Top tissues by expression

190 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of stomach	UBERON:0001199	75.46	gold quality
lower esophagus	UBERON:0013473	72.12	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.55	gold quality
esophagus	UBERON:0001043	64.81	gold quality
secondary oocyte	CL:0000655	60.06	gold quality
tibial artery	UBERON:0007610	59.33	gold quality
popliteal artery	UBERON:0002250	59.30	gold quality
right lung	UBERON:0002167	59.16	gold quality
upper lobe of left lung	UBERON:0008952	57.78	gold quality
upper lobe of lung	UBERON:0008948	56.38	gold quality
endocervix	UBERON:0000458	54.75	gold quality
aorta	UBERON:0000947	54.54	gold quality
left ovary	UBERON:0002119	54.41	gold quality
gastrocnemius	UBERON:0001388	53.71	gold quality
muscle of leg	UBERON:0001383	53.68	gold quality
calcaneal tendon	UBERON:0003701	53.34	silver quality
right hemisphere of cerebellum	UBERON:0014890	52.27	silver quality
urinary bladder	UBERON:0001255	51.86	gold quality
lung	UBERON:0002048	51.62	gold quality
body of stomach	UBERON:0001161	50.63	gold quality
stomach	UBERON:0000945	50.04	gold quality
cerebellar hemisphere	UBERON:0002245	50.02	silver quality
muscle layer of sigmoid colon	UBERON:0035805	49.84	gold quality
upper leg skin	UBERON:0004262	49.55	silver quality
fundus of stomach	UBERON:0001160	49.24	gold quality
skin of hip	UBERON:0001554	47.53	silver quality
anatomical system	UBERON:0000467	47.20	gold quality
multicellular organism	UBERON:0000468	46.91	gold quality
material anatomical entity	UBERON:0000465	46.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• NLC1-A, expressed in human hypothalamus, is considered to be a new resistance gene for human narcolepsy. (PMID:16826516)
• LINC00163 expression in gastric cancer can sponge miR-183 to promote AKAP12.LINC00163/miR-183/AKAP12 axis plays an important role in the gastric invasion and metastasis. (PMID:31894433)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.