LINC00165

Summary

LINC00165 (long intergenic non-protein coding RNA 165, HGNC:33166) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33166
Approved symbol	LINC00165
Name	long intergenic non-protein coding RNA 165
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	NLC1-B, AP001505.9
Ensembl gene	ENSG00000261706
Ensembl biotype	lncRNA
Entrez	727701
RNAcentral	URS00021231E0 — lncRNA, 841 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000569966

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000569966 — 1 exons

Exon	Start	End
ENSE00002621024	44994362	44995185

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 86.40.

Top tissues by expression

205 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.40	silver quality
right lung	UBERON:0002167	68.37	gold quality
descending thoracic aorta	UBERON:0002345	66.00	gold quality
thoracic aorta	UBERON:0001515	64.25	gold quality
ascending aorta	UBERON:0001496	64.08	gold quality
ganglionic eminence	UBERON:0004023	63.70	gold quality
aorta	UBERON:0000947	63.06	gold quality
popliteal artery	UBERON:0002250	62.39	gold quality
tibial artery	UBERON:0007610	62.37	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.28	gold quality
mucosa of stomach	UBERON:0001199	61.92	gold quality
spinal cord	UBERON:0002240	60.27	gold quality
left coronary artery	UBERON:0001626	59.85	gold quality
coronary artery	UBERON:0001621	58.53	gold quality
upper lobe of left lung	UBERON:0008952	58.17	gold quality
right coronary artery	UBERON:0001625	58.12	gold quality
upper lobe of lung	UBERON:0008948	56.15	gold quality
lower esophagus	UBERON:0013473	55.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	55.95	gold quality
esophagus	UBERON:0001043	54.30	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	54.05	gold quality
calcaneal tendon	UBERON:0003701	53.83	gold quality
prefrontal cortex	UBERON:0000451	52.19	gold quality
omental fat pad	UBERON:0010414	51.96	gold quality
peritoneum	UBERON:0002358	51.90	gold quality
skin of leg	UBERON:0001511	51.68	gold quality
lung	UBERON:0002048	51.22	gold quality
adipose tissue of abdominal region	UBERON:0007808	50.89	gold quality
monocyte	CL:0000576	50.28	silver quality
right ovary	UBERON:0002118	50.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• STAT3 could bind directly to the region between -547 bp to -537 bp (ATGTTGGGAAA) of LINC00165 promoter and activate its transcription. (PMID:30448060)
• Overexpression of long non-coding RNA AP001505.9 inhibits human hyaline chondrocyte dedifferentiation. (PMID:33839696)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.