LINC00173

Summary

LINC00173 (long intergenic non-protein coding RNA 173, HGNC:33791) is a long non-coding RNA gene on chromosome 12q24.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33791
Approved symbol	LINC00173
Name	long intergenic non-protein coding RNA 173
Location	12q24.22
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ42957
Ensembl gene	ENSG00000196668
Ensembl biotype	lncRNA
Entrez	100287569
RNAcentral	URS000075B380 — lncRNA, 1597 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 8 lncRNA, 1 retained_intron

ENST00000470091, ENST00000477702, ENST00000480237, ENST00000489452, ENST00000659479, ENST00000816203, ENST00000816204, ENST00000816205, ENST00000816206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000470091 — 3 exons

Exon	Start	End
ENSE00001831893	116536353	116536513
ENSE00001939740	116536120	116536211
ENSE00004218718	116533425	116533616

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 92.21.

FANTOM5 (CAGE): breadth broad, TPM avg 2.8964 / max 193.0262, expressed in 732 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128227	2.8665	725
128228	0.0299	13

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	92.21	gold quality
cerebellar cortex	UBERON:0002129	92.09	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.07	gold quality
cerebellum	UBERON:0002037	91.71	gold quality
blood	UBERON:0000178	85.80	gold quality
cerebellar vermis	UBERON:0004720	85.47	gold quality
left ovary	UBERON:0002119	85.21	gold quality
right uterine tube	UBERON:0001302	83.70	gold quality
right ovary	UBERON:0002118	83.64	gold quality
body of uterus	UBERON:0009853	83.23	gold quality
left uterine tube	UBERON:0001303	81.28	gold quality
spleen	UBERON:0002106	81.22	gold quality
monocyte	CL:0000576	80.98	gold quality
skin of abdomen	UBERON:0001416	80.66	gold quality
tibial nerve	UBERON:0001323	80.63	gold quality
mucosa of stomach	UBERON:0001199	80.59	gold quality
leukocyte	CL:0000738	80.17	gold quality
ovary	UBERON:0000992	79.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.17	silver quality
bone marrow cell	CL:0002092	77.65	gold quality
skin of leg	UBERON:0001511	77.56	gold quality
cortex of kidney	UBERON:0001225	77.29	gold quality
zone of skin	UBERON:0000014	77.00	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.89	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.86	gold quality
caudate nucleus	UBERON:0001873	76.78	gold quality
germinal epithelium of ovary	UBERON:0001304	76.68	gold quality
granulocyte	CL:0000094	76.45	gold quality
minor salivary gland	UBERON:0001830	76.23	gold quality
metanephros cortex	UBERON:0010533	75.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• Linc00173 upregulated Etk through functioning as a competitive endogenous RNA (ceRNA) by “sponging” miRNA-218 and led to the upregulation of GSKIP and NDRG1, resulting in the translocation of beta-catenin. Importantly, expression analysis revealed that both Linc00173 and Etk were upregulated in SCLC patient samples and exhibiting positive Linc00173/Etk correlation (PMID:31477834)
• Long noncoding RNA LINC00173 is downregulated in cervical cancer and inhibits cell proliferation and invasion by modulating the miR-182-5p/FBXW7 axis. (PMID:32402537)
• LINC00173.v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression. (PMID:32473645)
• Long intergenic noncoding RNA LINC00173 as a potential serum biomarker for diagnosis of non-small-cell lung cancer. (PMID:32623390)
• Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25. (PMID:33015770)
• LINC00173 promotes the apoptosis of hypertrophic scar fibroblasts through increasing beta-catenin expression. (PMID:33141309)
• Long Intergenic Nonprotein Coding RNA 173 Inhibits Tumor Growth and Promotes Apoptosis by Repressing Sphingosine Kinase 1 Protein Expression in Pancreatic Cancer. (PMID:33978457)
• LINC00173 Interacts With DNMT1 to Regulate LINC00173 Expression via Promoter Methylation in Hydroquinone-Induced Malignantly Transformed TK6 Cells and Benzene-Exposed Workers. (PMID:35135009)
• lncRNA Linc00173 modulates glucose metabolism and multidrug chemoresistance in SCLC: Potential molecular panel for targeted therapy. (PMID:35334209)
• LINC00173 facilitates tumor progression by stimulating RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal carcinoma. (PMID:36606322)
• Downregulation of Linc00173 increases BCL2 mRNA stability via the miR-1275/PROCA1/ZFP36L2 axis and induces acquired cisplatin resistance of lung adenocarcinoma. (PMID:36627670)
• A review on the role of LINC00173 in human cancers. (PMID:36774758)
• LINC00173 blocks GATA6-mediated transcription of COL5A1 to affect malignant development of oral squamous cell carcinoma. (PMID:36856154)
• Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway. (PMID:37258811)
• Long noncoding RNA long intergenic non-protein-coding RNA 173 contributes to nasopharyngeal carcinoma progression by regulating microRNA-765/Gremlin 1 pathway. (PMID:37365917)
• Expression of Tumor Suppressor FHIT Is Regulated by the LINC00173-SNAIL Axis in Human Lung Adenocarcinoma. (PMID:38069335)
• ER stress-induced LINC00173 promotes the apoptosis of ovarian granulosa cells by regulating the HRK/PI3K/AKT pathway in polycystic ovary syndrome. (PMID:39428498)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.