LINC00174

Summary

LINC00174 (long intergenic non-protein coding RNA 174, HGNC:27788) is a long non-coding RNA gene on chromosome 7q11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27788
Approved symbol	LINC00174
Name	long intergenic non-protein coding RNA 174
Location	7q11.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000179406
Ensembl biotype	lncRNA
Entrez	285908
RNAcentral	URS000075E19E — lncRNA, 4426 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000412091, ENST00000416366, ENST00000416572, ENST00000421767, ENST00000429320, ENST00000438894, ENST00000442578, ENST00000450353, ENST00000638517, ENST00000638592, ENST00000639086, ENST00000640964, ENST00000688360, ENST00000719397, ENST00000719398, ENST00000719399, ENST00000719400, ENST00000719401, ENST00000719402, ENST00000719403, ENST00000719404, ENST00000719405, ENST00000719406, ENST00000775452, ENST00000775453, ENST00000775454, ENST00000775455, ENST00000775456, ENST00000775457, ENST00000775458, ENST00000775459, ENST00000848847

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412091 — 3 exons

Exon	Start	End
ENSE00004037077	66491071	66491471
ENSE00004037083	66492008	66492339
ENSE00004037088	66493216	66493589

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 94.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.4525 / max 86.1505, expressed in 1539 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
84220	5.4964	1478
84221	0.8167	499
84219	0.1394	26

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	94.38	gold quality
left testis	UBERON:0004533	94.15	gold quality
right uterine tube	UBERON:0001302	91.88	gold quality
right adrenal gland	UBERON:0001233	90.27	gold quality
testis	UBERON:0000473	89.70	gold quality
right adrenal gland cortex	UBERON:0035827	89.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.12	gold quality
right lobe of liver	UBERON:0001114	88.85	gold quality
left adrenal gland	UBERON:0001234	88.62	gold quality
left adrenal gland cortex	UBERON:0035825	88.34	gold quality
right lobe of thyroid gland	UBERON:0001119	88.07	gold quality
sural nerve	UBERON:0015488	87.60	gold quality
left lobe of thyroid gland	UBERON:0001120	87.12	gold quality
left ovary	UBERON:0002119	86.68	gold quality
adrenal gland	UBERON:0002369	86.01	gold quality
body of pancreas	UBERON:0001150	85.92	gold quality
bone marrow cell	CL:0002092	85.79	gold quality
thyroid gland	UBERON:0002046	85.62	gold quality
right ovary	UBERON:0002118	85.37	gold quality
adrenal cortex	UBERON:0001235	85.27	gold quality
adenohypophysis	UBERON:0002196	85.25	gold quality
metanephros cortex	UBERON:0010533	84.78	gold quality
skin of leg	UBERON:0001511	83.73	gold quality
skin of abdomen	UBERON:0001416	83.53	gold quality
lower esophagus mucosa	UBERON:0035834	83.23	gold quality
colonic epithelium	UBERON:0000397	83.18	gold quality
tibial nerve	UBERON:0001323	82.98	gold quality
granulocyte	CL:0000094	82.69	gold quality
adrenal tissue	UBERON:0018303	82.61	gold quality
pituitary gland	UBERON:0000007	82.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	13.67

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• oncogenic role of LINC00174 in clinical colorectal cancer specimens and cellular experiments. (PMID:29729381)
• LINC00174 accelerated carcinogenesis of glioma via sponging miR-1523-3p and increasing the SLC2A1 expression, which could be considered as a molecular target for glioma diagnosis and therapy. (PMID:31492194)
• LINC00174 is an oncogenic lncRNA of hepatocellular carcinoma and regulates miR-320/S100A10 axis. (PMID:32128852)
• LINC00174 is a favorable prognostic biomarker in glioblastoma via promoting proliferative phenotype. (PMID:32390602)
• LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism. (PMID:33161413)
• LINC00174 Facilitates Proliferation and Migration of Colorectal Cancer Cells via MiR-3127-5p/ E2F7 Axis. (PMID:34226413)
• LINC00174 triggers the malignant development of breast cancer by negatively regulating miR-1827 level. (PMID:34787848)
• Downregulated long intergenic non-coding RNA 00,174 represses malignant biological behaviors of lung cancer cells by regulating microRNA-584-3p/ribosomal protein S24 axis. (PMID:35451652)
• LINC00174 promotes cell proliferation and metastasis in renal clear cell carcinoma by regulating miR-612/FOXM1 axis. (PMID:35616230)
• Expression of LINC00174 in different cancers: Review of the literature and bioinformatics analyses. (PMID:37320864)
• c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression. (PMID:37434557)
• LINC00174 Promotes Colon Cancer Progression by Regulating Inflammation and Glycolysis by Targeting the MicroRNA-2467-3p/Enolase 3 Axis. (PMID:37448887)
• [Effect of LINC00174 on the Malignant Proliferation of Multiple Myeloma Cells and Its Related Mechanism]. (PMID:37551481)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.