LINC00189

Summary

LINC00189 (long intergenic non-protein coding RNA 189, HGNC:18461) is a long non-coding RNA gene on chromosome 21q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18461
Approved symbol	LINC00189
Name	long intergenic non-protein coding RNA 189
Location	21q21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000215533
Ensembl biotype	lncRNA
Entrez	193629
RNAcentral	URS00007599E8 — lncRNA, 1045 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000420364, ENST00000431661, ENST00000447125, ENST00000802579

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420364 — 2 exons

Exon	Start	End
ENSE00001686651	29287984	29288205
ENSE00001806032	29193494	29194260

Expression profiles

Bgee: expression breadth ubiquitous, 144 present calls, max score 87.36.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6721 / max 46.2074, expressed in 247 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188743	0.3084	143
188741	0.1732	60
188742	0.1568	83
188740	0.0338	21

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.36	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.10	gold quality
monocyte	CL:0000576	74.78	gold quality
leukocyte	CL:0000738	74.50	gold quality
ganglionic eminence	UBERON:0004023	70.45	gold quality
stromal cell of endometrium	CL:0002255	64.57	gold quality
ventricular zone	UBERON:0003053	63.58	gold quality
right atrium auricular region	UBERON:0006631	63.34	gold quality
cardiac atrium	UBERON:0002081	62.75	gold quality
blood	UBERON:0000178	62.28	gold quality
right coronary artery	UBERON:0001625	62.01	gold quality
cortical plate	UBERON:0005343	62.01	gold quality
granulocyte	CL:0000094	61.65	gold quality
heart	UBERON:0000948	59.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.85	gold quality
heart left ventricle	UBERON:0002084	59.36	gold quality
gall bladder	UBERON:0002110	59.10	gold quality
vermiform appendix	UBERON:0001154	59.01	gold quality
cardiac ventricle	UBERON:0002082	58.68	gold quality
apex of heart	UBERON:0002098	58.28	gold quality
left coronary artery	UBERON:0001626	56.01	gold quality
lymph node	UBERON:0000029	56.00	gold quality
coronary artery	UBERON:0001621	55.60	gold quality
smooth muscle tissue	UBERON:0001135	55.54	gold quality
caecum	UBERON:0001153	54.87	gold quality
calcaneal tendon	UBERON:0003701	54.72	silver quality
left uterine tube	UBERON:0001303	54.10	gold quality
islet of Langerhans	UBERON:0000006	54.06	gold quality
right lobe of liver	UBERON:0001114	53.19	gold quality
tibial artery	UBERON:0007610	52.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.76

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.