LINC00205

Summary

LINC00205 (long intergenic non-protein coding RNA 205, HGNC:16420) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16420
Approved symbol	LINC00205
Name	long intergenic non-protein coding RNA 205
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LVBU
Ensembl gene	ENSG00000223768
Ensembl biotype	lncRNA
Entrez	642852
RNAcentral	URS000075D064 — lncRNA, 7181 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000400362, ENST00000433465, ENST00000454115, ENST00000647108, ENST00000652705, ENST00000689879, ENST00000701789, ENST00000716679, ENST00000716680, ENST00000716681, ENST00000716682, ENST00000716687, ENST00000757150, ENST00000757151, ENST00000757152, ENST00000757153, ENST00000757154, ENST00000757155, ENST00000757156, ENST00000757157, ENST00000757158, ENST00000757159, ENST00000757160, ENST00000757161

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000400362 — 3 exons

Exon	Start	End
ENSE00001714446	45289351	45289438
ENSE00004107950	45290471	45297806
ENSE00004107951	45287983	45288165

Expression profiles

Bgee: expression breadth ubiquitous, 223 present calls, max score 96.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.0829 / max 160.4835, expressed in 1745 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189540	12.0829	1745

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	96.57	gold quality
cortical plate	UBERON:0005343	95.25	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.12	gold quality
tendon of biceps brachii	UBERON:0008188	90.48	gold quality
middle temporal gyrus	UBERON:0002771	89.96	gold quality
ganglionic eminence	UBERON:0004023	89.65	gold quality
tibia	UBERON:0000979	89.02	gold quality
ventricular zone	UBERON:0003053	88.83	gold quality
hypothalamus	UBERON:0001898	88.41	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.96	gold quality
adrenal tissue	UBERON:0018303	87.86	gold quality
anterior cingulate cortex	UBERON:0009835	87.20	gold quality
epithelial cell of pancreas	CL:0000083	87.09	gold quality
entorhinal cortex	UBERON:0002728	86.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.81	gold quality
right frontal lobe	UBERON:0002810	85.72	gold quality
temporal lobe	UBERON:0001871	85.61	gold quality
amygdala	UBERON:0001876	85.50	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.40	gold quality
cerebral cortex	UBERON:0000956	85.22	gold quality
left ovary	UBERON:0002119	85.21	gold quality
Ammon’s horn	UBERON:0001954	85.19	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.16	gold quality
cerebellar hemisphere	UBERON:0002245	85.07	gold quality
cerebellar cortex	UBERON:0002129	84.91	gold quality
neocortex	UBERON:0001950	84.73	gold quality
primary visual cortex	UBERON:0002436	84.65	gold quality
cerebellum	UBERON:0002037	84.45	gold quality
forebrain	UBERON:0001890	84.04	gold quality
right ovary	UBERON:0002118	84.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.62

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• LINC00205 acted as a competing endogenous RNA by directly interacting with miR-122-5p in hepatocellular carcinoma (PMID:31272761)
• LINC00205 modulates the expression of EPHX1 through the inhibition of miR-184 in hepatocellular carcinoma as a ceRNA. (PMID:31566711)
• Long noncoding RNA LINC00205 enhances the malignant characteristics of retinoblastoma by acting as a molecular sponge of microRNA-665 and consequently increasing HMGB1 expression. (PMID:32223925)
• LINC00205 promotes malignancy in lung cancer by recruiting FUS and stabilizing CSDE1. (PMID:32808651)
• LINC00205 Promotes Tumor Malignancy of Lung Adenocarcinoma Through Sponging miR-185-5p. (PMID:34270733)
• LINC00205, a YY1-modulated lncRNA, serves as a sponge for miR-26a-5p facilitating the proliferation of hepatocellular carcinoma cells by elevating CDK6. (PMID:34730201)
• Long non-coding RNA Linc00205 promotes hepatoblastoma progression through regulating microRNA-154-3p/Rho-associated coiled-coil Kinase 1 axis via mitogen-activated protein kinase signaling. (PMID:35179516)
• LncRNA LINC00205 stimulates osteoporosis and contributes to spinal fracture through the regulation of the miR-26b-5p/KMT2C axis. (PMID:37016415)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.