LINC00221

Summary

LINC00221 (long intergenic non-protein coding RNA 221, HGNC:20169) is a long non-coding RNA gene on chromosome 14q32.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20169
Approved symbol	LINC00221
Name	long intergenic non-protein coding RNA 221
Location	14q32.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000270816
Ensembl biotype	lncRNA
Entrez	338005
RNAcentral	URS000075AA0C — lncRNA, 1752 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000603633, ENST00000619530, ENST00000620337, ENST00000659544

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000603633 — 3 exons

Exon	Start	End
ENSE00003597577	106488768	106488961
ENSE00003603032	106494157	106495588
ENSE00003747900	106482435	106482637

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 84.03.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8924 / max 73.0415, expressed in 127 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
207415	0.3243	93
141998	0.1945	71
141997	0.1688	65
141996	0.1040	47
207418	0.1008	36

Top tissues by expression

179 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.03	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.72	gold quality
left testis	UBERON:0004533	74.65	gold quality
right testis	UBERON:0004534	74.03	gold quality
testis	UBERON:0000473	72.50	gold quality
ganglionic eminence	UBERON:0004023	57.00	gold quality
monocyte	CL:0000576	55.53	gold quality
left adrenal gland cortex	UBERON:0035825	53.61	gold quality
left adrenal gland	UBERON:0001234	50.96	gold quality
hindlimb stylopod muscle	UBERON:0004252	50.44	silver quality
adrenal cortex	UBERON:0001235	50.35	gold quality
placenta	UBERON:0001987	50.19	gold quality
islet of Langerhans	UBERON:0000006	49.02	gold quality
adrenal tissue	UBERON:0018303	48.83	gold quality
muscle of leg	UBERON:0001383	48.23	gold quality
adrenal gland	UBERON:0002369	47.96	gold quality
lymph node	UBERON:0000029	47.60	silver quality
body of pancreas	UBERON:0001150	47.32	gold quality
pancreas	UBERON:0001264	47.14	gold quality
gastrocnemius	UBERON:0001388	46.58	gold quality
right adrenal gland cortex	UBERON:0035827	46.31	gold quality
vermiform appendix	UBERON:0001154	45.47	silver quality
skin of hip	UBERON:0001554	45.20	silver quality
blood	UBERON:0000178	45.18	gold quality
body of uterus	UBERON:0009853	45.11	gold quality
anatomical system	UBERON:0000467	44.96	gold quality
multicellular organism	UBERON:0000468	44.81	gold quality
material anatomical entity	UBERON:0000465	44.79	gold quality
Brodmann (1909) area 9	UBERON:0013540	44.69	silver quality
right lobe of liver	UBERON:0001114	44.47	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Linc00221 promotes cisplatin resistance in non-small-cell lung cancer (NSCLC) through the downstream miR-519a/ZBTB5 signaling axis, which could be used as a potential diagnostic and therapeutic target for clinical cisplatin-resistant NSCLC patients. (PMID:31029744)
• LINC00221 suppresses the malignancy of children acute lymphoblastic leukemia. (PMID:32297639)
• Downregulation of LINC00221 promotes angiopoiesis in HUVEC and inhibits recruitment of macrophages by augmenting miR-542-3p in trophoblast cells. (PMID:36069974)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.