LINC00222

Summary

LINC00222 (long intergenic non-protein coding RNA 222, HGNC:21560) is a long non-coding RNA gene on chromosome 6q21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21560
Approved symbol	LINC00222
Name	long intergenic non-protein coding RNA 222
Location	6q21
Locus type	RNA, long non-coding
Status	Approved
Aliases	dJ354J5.2
Ensembl gene	ENSG00000203801
Ensembl biotype	lncRNA
Entrez	387111
RNAcentral	URS000075B131 — lncRNA, 1753 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000368974, ENST00000416104, ENST00000416890, ENST00000417773, ENST00000430898, ENST00000444910, ENST00000448744, ENST00000655744, ENST00000667858, ENST00000720494, ENST00000720498, ENST00000720499, ENST00000720501, ENST00000720776, ENST00000720777

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000368974 — 4 exons

Exon	Start	End
ENSE00001448494	108768391	108769118
ENSE00001448495	108760302	108760403
ENSE00001448496	108759418	108759545
ENSE00001796415	108759165	108759323

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 71.82.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	71.82	gold quality
bone marrow cell	CL:0002092	70.76	silver quality
colonic epithelium	UBERON:0000397	67.89	silver quality
ventricular zone	UBERON:0003053	62.83	gold quality
sural nerve	UBERON:0015488	62.40	silver quality
ganglionic eminence	UBERON:0004023	61.52	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.17	gold quality
corpus callosum	UBERON:0002336	59.04	gold quality
lower esophagus mucosa	UBERON:0035834	58.78	gold quality
stromal cell of endometrium	CL:0002255	58.54	gold quality
popliteal artery	UBERON:0002250	58.17	gold quality
tibial artery	UBERON:0007610	58.10	gold quality
ascending aorta	UBERON:0001496	58.04	gold quality
monocyte	CL:0000576	57.88	gold quality
liver	UBERON:0002107	57.68	gold quality
thoracic aorta	UBERON:0001515	57.64	gold quality
leukocyte	CL:0000738	57.54	gold quality
descending thoracic aorta	UBERON:0002345	57.18	gold quality
left coronary artery	UBERON:0001626	56.90	gold quality
bone marrow	UBERON:0002371	56.57	silver quality
muscle of leg	UBERON:0001383	56.34	gold quality
gastrocnemius	UBERON:0001388	56.20	gold quality
myometrium	UBERON:0001296	55.40	gold quality
right lobe of liver	UBERON:0001114	55.13	gold quality
gall bladder	UBERON:0002110	55.00	gold quality
blood	UBERON:0000178	54.80	gold quality
uterine cervix	UBERON:0000002	54.67	gold quality
heart left ventricle	UBERON:0002084	54.56	gold quality
heart	UBERON:0000948	54.40	gold quality
urinary bladder	UBERON:0001255	54.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.89

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC00222 acts as a tumor suppressor in lung adenocarcinoma, regulating GSK3beta activity to promote tumor cell apoptosis. (PMID:29990868)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.