LINC00240

Summary

LINC00240 (long intergenic non-protein coding RNA 240, HGNC:18772) is a long non-coding RNA gene on chromosome 6p22.2.

Predicted to enable triplet codon-amino acid adaptor activity. Predicted to be involved in translation.

Source: NCBI Gene 100133205 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18772
Approved symbol	LINC00240
Name	long intergenic non-protein coding RNA 240
Location	6p22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	bA373D17.1
Ensembl gene	ENSG00000224843
Ensembl biotype	lncRNA
Entrez	100133205
RNAcentral	URS000075C5E2 — lncRNA, 983 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 37 — 37 lncRNA

ENST00000420081, ENST00000424968, ENST00000606878, ENST00000607607, ENST00000652085, ENST00000654448, ENST00000659035, ENST00000660952, ENST00000661007, ENST00000661575, ENST00000662403, ENST00000664092, ENST00000664178, ENST00000666341, ENST00000668297, ENST00000669756, ENST00000670365, ENST00000724049, ENST00000724050, ENST00000724051, ENST00000724052, ENST00000724053, ENST00000724054, ENST00000724055, ENST00000724056, ENST00000724057, ENST00000724058, ENST00000724059, ENST00000724060, ENST00000724061, ENST00000724062, ENST00000724063, ENST00000724064, ENST00000724065, ENST00000724066, ENST00000724067, ENST00000724068

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420081 — 4 exons

Exon	Start	End
ENSE00001690262	27023254	27023397
ENSE00003695647	26968458	26968522
ENSE00004046354	27023750	27023931
ENSE00004046368	26957048	26957183

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 90.72.

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	90.72	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.80	gold quality
endocervix	UBERON:0000458	77.36	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.08	gold quality
left lobe of thyroid gland	UBERON:0001120	76.96	gold quality
right testis	UBERON:0004534	76.88	gold quality
right lobe of liver	UBERON:0001114	76.66	gold quality
metanephros cortex	UBERON:0010533	76.46	gold quality
left testis	UBERON:0004533	76.45	gold quality
thyroid gland	UBERON:0002046	75.23	gold quality
right lobe of thyroid gland	UBERON:0001119	74.84	gold quality
left uterine tube	UBERON:0001303	74.79	gold quality
sural nerve	UBERON:0015488	74.12	gold quality
testis	UBERON:0000473	74.11	gold quality
body of pancreas	UBERON:0001150	73.73	gold quality
left ovary	UBERON:0002119	73.60	gold quality
right ovary	UBERON:0002118	72.32	gold quality
right lung	UBERON:0002167	72.18	gold quality
mucosa of stomach	UBERON:0001199	71.42	gold quality
pancreas	UBERON:0001264	71.36	gold quality
cortex of kidney	UBERON:0001225	70.51	gold quality
prostate gland	UBERON:0002367	70.49	gold quality
upper lobe of left lung	UBERON:0008952	70.05	gold quality
body of uterus	UBERON:0009853	69.93	gold quality
islet of Langerhans	UBERON:0000006	69.92	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.90	gold quality
adenohypophysis	UBERON:0002196	69.66	gold quality
popliteal artery	UBERON:0002250	69.36	gold quality
tibial artery	UBERON:0007610	69.36	gold quality
fallopian tube	UBERON:0003889	69.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Natural killer T cell cytotoxic activity in cervical cancer is facilitated by the LINC00240/microRNA-124-3p/STAT3/MICA axis. (PMID:31904481)
• LINC00240 sponges miR-4465 to promote proliferation, migration, and invasion of hepatocellular carcinoma cells via HGF/c-MET signaling pathway. (PMID:33155201)
• LncRNA LINC00240 suppresses invasion and migration in non-small cell lung cancer by sponging miR-7-5p. (PMID:33422052)
• Long non-coding RNA LINC00240 promotes gastric cancer progression via modulating miR-338-5p/METTL3 axis. (PMID:34842045)
• LINC00240 knockdown inhibits nasopharyngeal carcinoma progress by targeting miR-26a-5p. (PMID:35421264)
• LINC00240/miR-155 axis regulates function of trophoblasts and M2 macrophage polarization via modulating oxidative stress-induced pyroptosis in preeclampsia. (PMID:36153499)
• LARRPM restricts lung adenocarcinoma progression and M2 macrophage polarization through epigenetically regulating LINC00240 and CSF1. (PMID:36221069)
• Knockdown of Long Noncoding RNA LINC00240 Inhibits Esophageal Cancer Progression by Regulating miR-26a-5p. (PMID:36262998)
• LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization. (PMID:37072811)
• Role of LINC00240 on T-helper 9 differentiation in allergic rhinitis through influencing DNMT1-dependent methylation of PU.1. (PMID:37966708)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.