LINC00265

Summary

LINC00265 (long intergenic non-protein coding RNA 265, HGNC:28019) is a long non-coding RNA gene on chromosome 7p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28019
Approved symbol	LINC00265
Name	long intergenic non-protein coding RNA 265
Location	7p14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00265-1
Ensembl gene	ENSG00000188185
Ensembl biotype	lncRNA
Entrez	349114
RNAcentral	URS000075CC82 — lncRNA, 4651 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000340510, ENST00000448955, ENST00000654922, ENST00000656108, ENST00000656391, ENST00000656645, ENST00000658784, ENST00000665200, ENST00000666283, ENST00000668152, ENST00000674829, ENST00000675279, ENST00000675949, ENST00000755920, ENST00000755921, ENST00000755922, ENST00000755923, ENST00000755924, ENST00000755925, ENST00000755926, ENST00000850558

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000340510 — 12 exons

Exon	Start	End
ENSE00001410792	39791744	39793092
ENSE00001595861	39779271	39779385
ENSE00001628773	39780503	39780624
ENSE00001642916	39789354	39789544
ENSE00001660874	39782735	39782799
ENSE00001660897	39781235	39781351
ENSE00001666989	39791594	39791651
ENSE00001677581	39788482	39788604
ENSE00001679707	39771005	39771091
ENSE00001728459	39733632	39734044
ENSE00001779993	39767404	39767670
ENSE00001787079	39781744	39781885

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 98.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.3333 / max 105.4209, expressed in 1617 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
78270	5.0885	1498
78269	2.8385	1066
78271	0.4063	226

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	98.25	gold quality
right uterine tube	UBERON:0001302	91.48	gold quality
right testis	UBERON:0004534	91.17	gold quality
left testis	UBERON:0004533	90.69	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.93	gold quality
testis	UBERON:0000473	86.83	gold quality
cerebellar hemisphere	UBERON:0002245	86.14	gold quality
cerebellar cortex	UBERON:0002129	86.12	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.75	gold quality
cerebellum	UBERON:0002037	83.52	gold quality
right ovary	UBERON:0002118	82.42	gold quality
ectocervix	UBERON:0012249	82.18	gold quality
left ovary	UBERON:0002119	82.14	gold quality
adenohypophysis	UBERON:0002196	81.95	gold quality
tibial nerve	UBERON:0001323	81.81	gold quality
stromal cell of endometrium	CL:0002255	81.70	gold quality
endocervix	UBERON:0000458	81.69	gold quality
pituitary gland	UBERON:0000007	81.58	gold quality
body of uterus	UBERON:0009853	81.30	gold quality
granulocyte	CL:0000094	81.27	gold quality
mucosa of stomach	UBERON:0001199	80.73	gold quality
right adrenal gland cortex	UBERON:0035827	80.68	gold quality
skin of leg	UBERON:0001511	80.62	gold quality
right adrenal gland	UBERON:0001233	80.41	gold quality
left adrenal gland cortex	UBERON:0035825	80.40	gold quality
descending thoracic aorta	UBERON:0002345	80.39	gold quality
left adrenal gland	UBERON:0001234	80.01	gold quality
skin of abdomen	UBERON:0001416	79.91	gold quality
ascending aorta	UBERON:0001496	79.90	gold quality
minor salivary gland	UBERON:0001830	79.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• overexpression of LINC00265 suppressed the capability of proliferation, migration and invasion in acute myeloid leukemia cell lines. By using Western blot, further illustrated that LINC00265 activated PI3K/AKT signaling in AML cell lines. (PMID:30536332)
• LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of beta-catenin. (PMID:31527801)
• LINC00265 maintains hepatocyte proliferation during liver regeneration by targeting miRNA-28-5p. (PMID:33624782)
• A Transcription Factor ZNF384, Regulated by LINC00265, Activates the Expression of IFI30 to Stimulate Malignant Progression in Glioma. (PMID:38141017)
• LINC00265 can Serve as a Potential Biomarker for Predicting Increased Disease Risk, Systemic Inflammation, Disease Severity and Poor Prognosis in Sepsis. (PMID:38589355)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.