LINC00273

Summary

LINC00273 (long intergenic non-protein coding RNA 273, HGNC:38595) is a long non-coding RNA gene on chromosome 16p11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38595
Approved symbol	LINC00273
Name	long intergenic non-protein coding RNA 273
Location	16p11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	TOP, NCRNA00273-1
Ensembl gene	ENSG00000256642
Ensembl biotype	lncRNA
Entrez	649159
RNAcentral	URS00002B9FE9 — lncRNA, 1452 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000539813

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000539813 — 1 exons

Exon	Start	End
ENSE00002302664	34158585	34160036

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 97.37.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.37	gold quality
bone marrow cell	CL:0002092	92.71	gold quality
bone marrow	UBERON:0002371	88.23	gold quality
colonic epithelium	UBERON:0000397	85.29	gold quality
tonsil	UBERON:0002372	81.11	gold quality
mucosa of transverse colon	UBERON:0004991	79.30	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.03	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.14	gold quality
skeletal muscle tissue	UBERON:0001134	74.17	gold quality
lower esophagus mucosa	UBERON:0035834	73.24	gold quality
liver	UBERON:0002107	72.93	gold quality
muscle tissue	UBERON:0002385	72.72	gold quality
blood	UBERON:0000178	72.18	gold quality
urinary bladder	UBERON:0001255	70.40	gold quality
right lobe of liver	UBERON:0001114	69.53	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.47	gold quality
lymph node	UBERON:0000029	67.19	gold quality
uterine cervix	UBERON:0000002	66.97	gold quality
thoracic mammary gland	UBERON:0005200	66.33	gold quality
tibial nerve	UBERON:0001323	65.87	gold quality
ventricular zone	UBERON:0003053	64.77	gold quality
kidney	UBERON:0002113	64.57	gold quality
adipose tissue	UBERON:0001013	64.54	gold quality
skin of abdomen	UBERON:0001416	64.52	gold quality
zone of skin	UBERON:0000014	63.63	gold quality
cortex of kidney	UBERON:0001225	62.78	gold quality
skin of leg	UBERON:0001511	62.69	gold quality
ectocervix	UBERON:0012249	62.08	gold quality
prostate gland	UBERON:0002367	62.07	gold quality
primary visual cortex	UBERON:0002436	62.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• T17 (TOP) is a protein specifically expressed in human testis, ovary and placenta (PMID:15353267)
• LINC00273 is involved in regulating cancer cell metastasis, migration and invasion. Its expression is correlated with degree of cellular dedifferentiation. LINC00273 harbors a unique (4n-1) parallel G-Quadruplex structure in its promoter which makes it a prominent target of anti-metastatic drug M2. (PMID:29299144)
• Study found that lncTIC1 is highly expressed in liver tumor-initiating cells (TICs) and required for the self-renewal of liver TICs. LncTIC1 drove liver TIC self-renewal through Wnt/beta-catenin signaling. LncTIC1 interacted with the N terminal of beta-catenin and inhibited the phosphorylation of beta-catenin, finally maintaining the stability of beta-catenin to drive the activation of Wnt/beta-catenin signaling and li… (PMID:29778568)
• LINC00273 modulates lung cancer metastasis through ZEB1 regulation. TGF-beta induced invasion and metastasis of A549 cells is accompanied by an upregulation of LINC00273 expression. LINC00273 upregulation makes ZEB1 free by sponging miR200a-3p and enhancing TGF-beta induced metastasis. (PMID:32017082)
• Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway. (PMID:34586722)
• Long non-coding intergenic RNA, LINC00273 induces cancer metastasis and stemness via miRNA sponging in triple negative breast cancer. (PMID:38857735)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.