LINC00278

Summary

LINC00278 (long intergenic non-protein coding RNA 278, HGNC:38712) is a long non-coding RNA gene on chromosome Yp11.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38712
Approved symbol	LINC00278
Name	long intergenic non-protein coding RNA 278
Location	Yp11.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	YY1BM
Ensembl gene	ENSG00000231535
Ensembl biotype	lncRNA
Entrez	100873962
RNAcentral	URS000075DF56 — lncRNA, 537 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000425031, ENST00000444263, ENST00000651090, ENST00000652068, ENST00000653660, ENST00000654222, ENST00000655607, ENST00000665487, ENST00000685199, ENST00000691894, ENST00000803190, ENST00000803191, ENST00000803192, ENST00000803193, ENST00000803194, ENST00000803195, ENST00000803196, ENST00000803197

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425031 — 4 exons

Exon	Start	End
ENSE00001620860	3096995	3097056
ENSE00001757585	3079284	3079341
ENSE00004193370	3002906	3003217
ENSE00004193379	3102085	3102272

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 89.69.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3562 / max 22.8371, expressed in 144 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201097	0.3562	144

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	89.69	gold quality
colonic epithelium	UBERON:0000397	83.52	gold quality
bone marrow	UBERON:0002371	83.02	gold quality
sural nerve	UBERON:0015488	82.39	gold quality
calcaneal tendon	UBERON:0003701	82.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.46	gold quality
tonsil	UBERON:0002372	76.62	gold quality
rectum	UBERON:0001052	74.10	gold quality
duodenum	UBERON:0002114	73.47	gold quality
esophagus mucosa	UBERON:0002469	69.96	gold quality
thyroid gland	UBERON:0002046	69.06	gold quality
right coronary artery	UBERON:0001625	69.01	gold quality
mucosa of transverse colon	UBERON:0004991	68.99	gold quality
adrenal tissue	UBERON:0018303	68.95	gold quality
blood	UBERON:0000178	68.80	gold quality
descending thoracic aorta	UBERON:0002345	68.76	gold quality
corpus callosum	UBERON:0002336	68.53	gold quality
thoracic aorta	UBERON:0001515	68.09	gold quality
kidney	UBERON:0002113	67.83	gold quality
left lobe of thyroid gland	UBERON:0001120	67.81	gold quality
ascending aorta	UBERON:0001496	67.71	gold quality
transverse colon	UBERON:0001157	67.58	gold quality
metanephros cortex	UBERON:0010533	67.56	gold quality
popliteal artery	UBERON:0002250	67.54	gold quality
tibial artery	UBERON:0007610	67.52	gold quality
small intestine	UBERON:0002108	67.13	gold quality
adult mammalian kidney	UBERON:0000082	67.10	gold quality
urinary bladder	UBERON:0001255	66.93	gold quality
cortex of kidney	UBERON:0001225	66.87	gold quality
intestine	UBERON:0000160	66.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The ETS1-LINC00278 negative feedback loop plays a role in COL4A1/COL4A2 regulation in laryngeal squamous cell carcinoma. (PMID:35532293)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.