LINC00294

Summary

LINC00294 (long intergenic non-protein coding RNA 294, HGNC:27456) is a long non-coding RNA gene on chromosome 11p13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27456
Approved symbol	LINC00294
Name	long intergenic non-protein coding RNA 294
Location	11p13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000280798
Ensembl biotype	lncRNA
OMIM	612296
Entrez	283267
RNAcentral	URS0000759AD2 — lncRNA, 3322 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000631190

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000631190 — 1 exons

Exon	Start	End
ENSE00003763791	33076149	33079454

Expression profiles

Bgee: expression breadth ubiquitous, 225 present calls, max score 96.21.

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ileal mucosa	UBERON:0000331	96.21	gold quality
substantia nigra pars compacta	UBERON:0001965	93.40	gold quality
Brodmann (1909) area 46	UBERON:0006483	92.98	gold quality
lateral nuclear group of thalamus	UBERON:0002736	92.57	gold quality
substantia nigra pars reticulata	UBERON:0001966	91.81	gold quality
entorhinal cortex	UBERON:0002728	91.25	gold quality
postcentral gyrus	UBERON:0002581	90.99	gold quality
pons	UBERON:0000988	90.90	gold quality
superior frontal gyrus	UBERON:0002661	90.57	gold quality
parietal lobe	UBERON:0001872	90.16	gold quality
superior vestibular nucleus	UBERON:0007227	89.58	gold quality
dorsal plus ventral thalamus	UBERON:0001897	89.44	gold quality
subthalamic nucleus	UBERON:0001906	89.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	88.58	gold quality
midbrain	UBERON:0001891	88.57	gold quality
substantia nigra	UBERON:0002038	88.56	gold quality
dorsal root ganglion	UBERON:0000044	88.35	gold quality
frontal cortex	UBERON:0001870	88.35	gold quality
prefrontal cortex	UBERON:0000451	88.26	gold quality
middle temporal gyrus	UBERON:0002771	88.12	gold quality
cerebral cortex	UBERON:0000956	88.05	gold quality
neocortex	UBERON:0001950	87.97	gold quality
medulla oblongata	UBERON:0001896	87.91	gold quality
temporal lobe	UBERON:0001871	87.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	87.76	gold quality
anterior cingulate cortex	UBERON:0009835	87.75	gold quality
pancreatic ductal cell	CL:0002079	87.65	silver quality
ventral tegmental area	UBERON:0002691	87.61	gold quality
right frontal lobe	UBERON:0002810	87.41	gold quality
Ammon’s horn	UBERON:0001954	87.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LINC00294 negatively modulates cell proliferation in glioma through a neurofilament medium-mediated pathway via interacting with miR-1278. (PMID:32450002)
• BakkenolideIIIa ameliorates lipopolysaccharideinduced inflammatory injury in human umbilical vein endothelial cells by upregulating LINC00294. (PMID:33760129)
• Silencing LINC00294 Restores Mitochondrial Function and Inhibits Apoptosis of Glioma Cells under Hypoxia via the miR-21-5p/CASKIN1/cAMP Axis. (PMID:34777696)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.