LINC00305

Summary

LINC00305 (long intergenic non-protein coding RNA 305, HGNC:28597) is a long non-coding RNA gene on chromosome 18q22.1.

Predicted to be located in extracellular region.

Source: NCBI Gene 221241 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28597
Approved symbol	LINC00305
Name	long intergenic non-protein coding RNA 305
Location	18q22.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC39571, HsT1235
Ensembl gene	ENSG00000179676
Ensembl biotype	lncRNA
OMIM	617489
Entrez	221241
RNAcentral	URS0002853AE3 — lncRNA, 945 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000323355, ENST00000454647, ENST00000456505, ENST00000657385, ENST00000657912, ENST00000658718, ENST00000659895, ENST00000662600, ENST00000663021, ENST00000665443, ENST00000665461, ENST00000666468, ENST00000668958, ENST00000669361, ENST00000669878, ENST00000671534, ENST00000718129, ENST00000718130, ENST00000718131, ENST00000718132, ENST00000718133, ENST00000718134, ENST00000718135, ENST00000718136, ENST00000718137, ENST00000718138, ENST00000718139, ENST00000718140, ENST00000718141, ENST00000844916, ENST00000844917, ENST00000844918

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000323355 — 4 exons

Exon	Start	End
ENSE00001264915	64148775	64149030
ENSE00002059243	64098577	64098640
ENSE00004034251	64080009	64080402
ENSE00004034262	64097834	64097992

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 75.31.

Top tissues by expression

198 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	75.31	gold quality
left testis	UBERON:0004533	70.11	gold quality
right testis	UBERON:0004534	68.73	gold quality
testis	UBERON:0000473	68.15	gold quality
ventricular zone	UBERON:0003053	66.50	gold quality
monocyte	CL:0000576	58.53	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.99	gold quality
buccal mucosa cell	CL:0002336	57.96	gold quality
sperm	CL:0000019	52.63	gold quality
right frontal lobe	UBERON:0002810	52.11	gold quality
islet of Langerhans	UBERON:0000006	51.66	gold quality
gastrocnemius	UBERON:0001388	50.80	gold quality
prefrontal cortex	UBERON:0000451	49.88	gold quality
calcaneal tendon	UBERON:0003701	49.85	silver quality
right adrenal gland	UBERON:0001233	49.46	gold quality
left coronary artery	UBERON:0001626	48.41	gold quality
pancreas	UBERON:0001264	47.85	gold quality
body of pancreas	UBERON:0001150	47.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	47.05	gold quality
thoracic aorta	UBERON:0001515	46.92	gold quality
adult mammalian kidney	UBERON:0000082	46.91	gold quality
nucleus accumbens	UBERON:0001882	46.45	gold quality
right atrium auricular region	UBERON:0006631	45.83	gold quality
tibial nerve	UBERON:0001323	45.77	gold quality
kidney	UBERON:0002113	45.71	gold quality
corpus callosum	UBERON:0002336	45.63	gold quality
left adrenal gland	UBERON:0001234	45.40	gold quality
body of uterus	UBERON:0009853	45.35	gold quality
aorta	UBERON:0000947	45.21	gold quality
lateral nuclear group of thalamus	UBERON:0002736	45.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC00305 promotes monocyte inflammation by facilitating LIMR and AHRR cooperation and the AHRR activation. (PMID:28393844)
• Serum LINC00305 expression and its genetic variant rs2850711 are associated with clinical and laboratory features of rheumatoid arthritis. (PMID:32188348)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.