LINC00309

Summary

LINC00309 (long intergenic non-protein coding RNA 309, HGNC:25279) is a long non-coding RNA gene on chromosome 2p14.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25279
Approved symbol	LINC00309
Name	long intergenic non-protein coding RNA 309
Location	2p14
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230923
Ensembl biotype	lncRNA
Entrez	150992
RNAcentral	URS0000759BFB — lncRNA, 3314 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000431020, ENST00000648144

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000431020 — 6 exons

Exon	Start	End
ENSE00001631997	64189017	64189132
ENSE00001639689	64202993	64203088
ENSE00001702617	64203290	64205485
ENSE00001705423	64201228	64201358
ENSE00001735316	64192356	64192458
ENSE00001743049	64185078	64185742

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 68.59.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8205 / max 188.1300, expressed in 127 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
28745	0.5386	105
28746	0.1365	49
28743	0.0832	24
28744	0.0622	18

Top tissues by expression

167 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	68.59	silver quality
gastrocnemius	UBERON:0001388	57.87	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.60	gold quality
tibialis anterior	UBERON:0001385	55.55	silver quality
cardiac muscle of right atrium	UBERON:0003379	54.96	gold quality
islet of Langerhans	UBERON:0000006	54.79	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
epithelial cell of pancreas	CL:0000083	53.52	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
monocyte	CL:0000576	52.48	gold quality
cardiac atrium	UBERON:0002081	52.21	gold quality
deltoid	UBERON:0001476	51.90	gold quality
pancreatic ductal cell	CL:0002079	50.68	silver quality
myocardium	UBERON:0002349	50.51	gold quality
ileal mucosa	UBERON:0000331	48.22	silver quality
pancreas	UBERON:0001264	47.53	gold quality
tibial artery	UBERON:0007610	47.49	gold quality
nasal cavity epithelium	UBERON:0005384	47.03	gold quality
quadriceps femoris	UBERON:0001377	46.99	gold quality
prefrontal cortex	UBERON:0000451	46.88	silver quality
vermiform appendix	UBERON:0001154	46.22	gold quality
metanephros	UBERON:0000081	46.07	gold quality
vastus lateralis	UBERON:0001379	45.40	gold quality
skeletal muscle tissue	UBERON:0001134	45.31	gold quality
adult mammalian kidney	UBERON:0000082	44.98	gold quality
upper leg skin	UBERON:0004262	44.87	silver quality
body of stomach	UBERON:0001161	44.72	silver quality
aorta	UBERON:0000947	44.51	silver quality
buccal mucosa cell	CL:0002336	44.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• in this paper we have showed that evolutionary new genes DCD1(Dermicidin), LINC00309 and CLLU1 have tumor-specific expression profile (PMID:30463107)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.