LINC00311

Summary

LINC00311 (long intergenic non-protein coding RNA 311, HGNC:28312) is a long non-coding RNA gene on chromosome 16q24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28312
Approved symbol	LINC00311
Name	long intergenic non-protein coding RNA 311
Location	16q24.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC22001
Ensembl gene	ENSG00000179219
Ensembl biotype	lncRNA
Entrez	197196
RNAcentral	URS00002295EA — lncRNA, 1566 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000366314

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366314 — 2 exons

Exon	Start	End
ENSE00001315394	85284998	85285963
ENSE00001648839	85282958	85283557

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 66.61.

Top tissues by expression

178 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	66.61	silver quality
hindlimb stylopod muscle	UBERON:0004252	62.76	gold quality
gastrocnemius	UBERON:0001388	58.93	gold quality
buccal mucosa cell	CL:0002336	58.84	gold quality
muscle of leg	UBERON:0001383	58.76	gold quality
ganglionic eminence	UBERON:0004023	55.65	silver quality
myocardium	UBERON:0002349	55.02	gold quality
vena cava	UBERON:0004087	54.87	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	54.66	gold quality
leukocyte	CL:0000738	53.55	silver quality
parietal pleura	UBERON:0002400	53.10	gold quality
heart right ventricle	UBERON:0002080	52.95	gold quality
upper leg skin	UBERON:0004262	52.87	gold quality
visceral pleura	UBERON:0002401	52.63	gold quality
nasal cavity epithelium	UBERON:0005384	52.59	gold quality
cerebellar vermis	UBERON:0004720	51.57	gold quality
monocyte	CL:0000576	51.20	silver quality
lateral globus pallidus	UBERON:0002476	50.93	gold quality
skeletal muscle tissue	UBERON:0001134	50.16	silver quality
right lobe of liver	UBERON:0001114	49.97	gold quality
islet of Langerhans	UBERON:0000006	49.66	gold quality
prefrontal cortex	UBERON:0000451	49.09	silver quality
quadriceps femoris	UBERON:0001377	48.70	gold quality
vastus lateralis	UBERON:0001379	48.55	gold quality
caecum	UBERON:0001153	48.22	gold quality
subthalamic nucleus	UBERON:0001906	47.69	gold quality
body of tongue	UBERON:0011876	47.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.38	silver quality
pancreas	UBERON:0001264	47.19	gold quality
renal medulla	UBERON:0000362	46.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Study found that plasma LINC00311 was upregulated in ankylosing spondylitis (AS) patients comparing to healthy controls, and upregulation of LINC00311 distinguished AS patients from healthy controls. LINC00311 expression levels were positively correlated with disease activity suggesting that plasma LINC00311 may be a potential diagnostic marker for AS. (PMID:31170957)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.