LINC00313

Summary

LINC00313 (long intergenic non-protein coding RNA 313, HGNC:16416) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16416
Approved symbol	LINC00313
Name	long intergenic non-protein coding RNA 313
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000185186
Ensembl biotype	lncRNA
Entrez	114038
RNAcentral	URS0000462C8A — lncRNA, 579 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 68 — 68 lncRNA

ENST00000332440, ENST00000413721, ENST00000418516, ENST00000426942, ENST00000427188, ENST00000441283, ENST00000451543, ENST00000651216, ENST00000663956, ENST00000782250, ENST00000782251, ENST00000782252, ENST00000782253, ENST00000782254, ENST00000782255, ENST00000782256, ENST00000782257, ENST00000782258, ENST00000782259, ENST00000782260, ENST00000782261, ENST00000782262, ENST00000782263, ENST00000782264, ENST00000782265, ENST00000782266, ENST00000782267, ENST00000782268, ENST00000782269, ENST00000782270, ENST00000782271, ENST00000782272, ENST00000782273, ENST00000782274, ENST00000782275, ENST00000782276, ENST00000782277, ENST00000782278, ENST00000782279, ENST00000782280, ENST00000782281, ENST00000782282, ENST00000782283, ENST00000782284, ENST00000782285, ENST00000782286, ENST00000782287, ENST00000782288, ENST00000782289, ENST00000782290, ENST00000782291, ENST00000782292, ENST00000782293, ENST00000782294, ENST00000782295, ENST00000782296, ENST00000782297, ENST00000782298, ENST00000782299, ENST00000782300, ENST00000782301, ENST00000782302, ENST00000782303, ENST00000782304, ENST00000782305, ENST00000782306, ENST00000782307, ENST00000782308

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000332440 — 4 exons

Exon	Start	End
ENSE00001305748	43475972	43476039
ENSE00001330292	43471512	43471694
ENSE00004155158	43478064	43478281
ENSE00004155245	43461903	43462261

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 81.80.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	81.80	gold quality
liver	UBERON:0002107	81.12	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.88	gold quality
left testis	UBERON:0004533	78.27	gold quality
right testis	UBERON:0004534	77.87	gold quality
testis	UBERON:0000473	77.30	gold quality
lower esophagus mucosa	UBERON:0035834	76.23	gold quality
left ovary	UBERON:0002119	74.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	74.30	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.86	gold quality
adipose tissue	UBERON:0001013	73.10	gold quality
sural nerve	UBERON:0015488	72.95	gold quality
ovary	UBERON:0000992	72.63	gold quality
omental fat pad	UBERON:0010414	72.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.96	gold quality
right lung	UBERON:0002167	71.47	gold quality
adenohypophysis	UBERON:0002196	70.92	gold quality
right ovary	UBERON:0002118	70.76	gold quality
gall bladder	UBERON:0002110	70.29	gold quality
left adrenal gland cortex	UBERON:0035825	69.93	gold quality
upper lobe of left lung	UBERON:0008952	69.89	gold quality
heart left ventricle	UBERON:0002084	69.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.63	gold quality
lower esophagus	UBERON:0013473	68.53	gold quality
right atrium auricular region	UBERON:0006631	68.51	gold quality
tibial nerve	UBERON:0001323	68.43	gold quality
thoracic mammary gland	UBERON:0005200	68.35	gold quality
left uterine tube	UBERON:0001303	68.30	gold quality
gastrocnemius	UBERON:0001388	67.98	gold quality
endocervix	UBERON:0000458	67.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• LINC00313 acts as an oncogene in papillary thyroid cancer via sponging miR-4429 (PMID:29940766)
• LINC00313 functioned as an oncogene in papillary thyroid cancer in part through serving as a competing endogenous RNA to modulate mi-422a expression. (PMID:30779082)
• LINC00313/miR-4429 axis provides novel biomarkers for the diagnosis and prognosis of non-small cell lung cancer. (PMID:35485050)
• LINC00313 regulates the metastasis of testicular germ cell tumors through epithelial-mesenchyme transition and immune pathways. (PMID:35575252)
• LINC00313 promotes the proliferation and inhibits the apoptosis of chondrocytes via regulating miR-525-5p/GDF5 axis. (PMID:36823651)
• TGFbeta-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma. (PMID:38332153)
• Biomarker Potential of LINC00313 in Head and Neck Squamous Cell Carcinoma: Correlation with Epithelial-Mesenchymal Transition and Immune Cell Infiltration. (PMID:38617010)
• LINC00313 suppresses autophagy and promotes stemness of nasopharyngeal carcinoma cells through PTBP1/STIM1 axis. (PMID:38677328)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.