LINC00314

Summary

LINC00314 (long intergenic non-protein coding RNA 314, HGNC:16622) is a long non-coding RNA gene on chromosome 21q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16622
Approved symbol	LINC00314
Name	long intergenic non-protein coding RNA 314
Location	21q21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000178457
Ensembl biotype	lncRNA
Entrez	246705
RNAcentral	URS0000759B51 — lncRNA, 583 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000324988, ENST00000433344, ENST00000717186

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000324988 — 6 exons

Exon	Start	End
ENSE00001247220	28022697	28022954
ENSE00001359731	28013176	28013432
ENSE00004031853	27995982	27996087
ENSE00004031854	27954905	27955023
ENSE00004031856	27993317	27993385
ENSE00004031857	27977909	27978122

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 79.04.

Top tissues by expression

218 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.04	silver quality
sural nerve	UBERON:0015488	73.16	gold quality
calcaneal tendon	UBERON:0003701	66.08	gold quality
colonic epithelium	UBERON:0000397	62.30	silver quality
lower lobe of lung	UBERON:0008949	57.93	silver quality
ganglionic eminence	UBERON:0004023	57.91	gold quality
monocyte	CL:0000576	57.72	gold quality
tendon	UBERON:0000043	55.61	gold quality
left uterine tube	UBERON:0001303	54.24	gold quality
buccal mucosa cell	CL:0002336	53.60	silver quality
stromal cell of endometrium	CL:0002255	53.59	silver quality
minor salivary gland	UBERON:0001830	51.51	gold quality
islet of Langerhans	UBERON:0000006	50.95	gold quality
vermiform appendix	UBERON:0001154	50.48	gold quality
prefrontal cortex	UBERON:0000451	50.31	gold quality
mouth mucosa	UBERON:0003729	49.78	gold quality
left adrenal gland cortex	UBERON:0035825	48.71	gold quality
right lobe of liver	UBERON:0001114	48.41	silver quality
saliva-secreting gland	UBERON:0001044	48.12	gold quality
gastrocnemius	UBERON:0001388	48.05	silver quality
pancreas	UBERON:0001264	47.25	gold quality
Ammon’s horn	UBERON:0001954	47.15	gold quality
stomach	UBERON:0000945	47.12	gold quality
urinary bladder	UBERON:0001255	46.83	silver quality
Brodmann (1909) area 9	UBERON:0013540	46.82	gold quality
right ovary	UBERON:0002118	46.77	gold quality
right frontal lobe	UBERON:0002810	46.74	gold quality
middle temporal gyrus	UBERON:0002771	46.61	gold quality
omental fat pad	UBERON:0010414	46.34	gold quality
right adrenal gland	UBERON:0001233	46.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose-derived stem cells through the hsa-miR-129-5p/GRM5 axis via the Wnt signaling pathway. (PMID:32552820)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.