LINC00315

Summary

LINC00315 (long intergenic non-protein coding RNA 315, HGNC:16621) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16621
Approved symbol	LINC00315
Name	long intergenic non-protein coding RNA 315
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000184274
Ensembl biotype	lncRNA
Entrez	246704
RNAcentral	URS000037457A — lncRNA, 2323 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 28 — 28 lncRNA

ENST00000441947, ENST00000757485, ENST00000757486, ENST00000757487, ENST00000757488, ENST00000757489, ENST00000757490, ENST00000757491, ENST00000757492, ENST00000757493, ENST00000757494, ENST00000757495, ENST00000757496, ENST00000757497, ENST00000757498, ENST00000757499, ENST00000757500, ENST00000757501, ENST00000757502, ENST00000757503, ENST00000757504, ENST00000757505, ENST00000757506, ENST00000757507, ENST00000757508, ENST00000757509, ENST00000757510, ENST00000757511

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441947 — 3 exons

Exon	Start	End
ENSE00001639661	45302258	45303515
ENSE00001752111	45300245	45300539
ENSE00002063048	45304488	45305257

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 66.22.

Top tissues by expression

200 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	66.22	gold quality
popliteal artery	UBERON:0002250	59.24	gold quality
tibial artery	UBERON:0007610	59.18	gold quality
aorta	UBERON:0000947	53.79	gold quality
skin of hip	UBERON:0001554	53.60	silver quality
epithelium of nasopharynx	UBERON:0001951	52.92	gold quality
oocyte	CL:0000023	50.57	gold quality
left coronary artery	UBERON:0001626	50.39	gold quality
coronary artery	UBERON:0001621	49.46	gold quality
muscle of leg	UBERON:0001383	48.50	gold quality
hindlimb stylopod muscle	UBERON:0004252	48.29	silver quality
gastrocnemius	UBERON:0001388	48.12	gold quality
upper leg skin	UBERON:0004262	46.99	silver quality
Brodmann (1909) area 9	UBERON:0013540	46.86	gold quality
right coronary artery	UBERON:0001625	46.70	gold quality
heart left ventricle	UBERON:0002084	45.87	gold quality
vermiform appendix	UBERON:0001154	45.80	silver quality
heart	UBERON:0000948	45.62	gold quality
cardiac ventricle	UBERON:0002082	45.37	gold quality
islet of Langerhans	UBERON:0000006	45.35	silver quality
gall bladder	UBERON:0002110	45.05	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	44.95	silver quality
adrenal tissue	UBERON:0018303	44.54	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	44.40	gold quality
cerebellar hemisphere	UBERON:0002245	44.21	silver quality
right frontal lobe	UBERON:0002810	44.07	gold quality
left ovary	UBERON:0002119	44.03	silver quality
nipple	UBERON:0002030	44.02	gold quality
right atrium auricular region	UBERON:0006631	43.95	silver quality
cardiac atrium	UBERON:0002081	43.75	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.96

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The LINC00315/C21orf93 promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. (PMID:20494980)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.