LINC00319

Summary

LINC00319 (long intergenic non-protein coding RNA 319, HGNC:19730) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19730
Approved symbol	LINC00319
Name	long intergenic non-protein coding RNA 319
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRED49, FLJ38036
Ensembl gene	ENSG00000188660
Ensembl biotype	lncRNA
Entrez	284836
RNAcentral	URS0000499971 — lncRNA, 3507 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000342757, ENST00000448049, ENST00000651768, ENST00000701366, ENST00000782684, ENST00000782685, ENST00000782686

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000342757 — 3 exons

Exon	Start	End
ENSE00001365651	43451173	43452505
ENSE00001380650	43453121	43453902
ENSE00001391090	43450024	43450921

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 61.12.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0076 / max 1.3241, expressed in 2 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189365	0.0076	2

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	61.12	gold quality
sural nerve	UBERON:0015488	60.25	silver quality
liver	UBERON:0002107	59.81	gold quality
cortical plate	UBERON:0005343	59.78	silver quality
ventricular zone	UBERON:0003053	58.79	silver quality
body of stomach	UBERON:0001161	58.73	gold quality
right lobe of liver	UBERON:0001114	58.66	gold quality
body of pancreas	UBERON:0001150	58.58	gold quality
ganglionic eminence	UBERON:0004023	58.51	gold quality
pancreas	UBERON:0001264	58.35	gold quality
lower esophagus mucosa	UBERON:0035834	57.95	gold quality
stomach	UBERON:0000945	57.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	55.58	gold quality
myometrium	UBERON:0001296	55.08	gold quality
muscle tissue	UBERON:0002385	54.85	gold quality
skin of abdomen	UBERON:0001416	54.81	gold quality
zone of skin	UBERON:0000014	54.79	gold quality
skin of leg	UBERON:0001511	54.76	gold quality
body of uterus	UBERON:0009853	54.67	gold quality
heart left ventricle	UBERON:0002084	53.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	52.92	gold quality
fundus of stomach	UBERON:0001160	52.61	gold quality
skeletal muscle tissue	UBERON:0001134	51.79	silver quality
adenohypophysis	UBERON:0002196	51.52	gold quality
pituitary gland	UBERON:0000007	51.18	gold quality
heart	UBERON:0000948	51.06	gold quality
muscle of leg	UBERON:0001383	51.01	gold quality
gastrocnemius	UBERON:0001388	50.88	gold quality
small intestine	UBERON:0002108	50.87	gold quality
left uterine tube	UBERON:0001303	50.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• The LINC00319/C21orf125 promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. (PMID:20494980)
• Confirmation of an oncogenic role for LINC00319 in clinical specimens and cellular experiments, showing the potential LINC00319/miR-450b-5p/EZH2 pathway in lung adenocarcinoma tumorigenesis. (PMID:29408583)
• LINC00319 is highly expressed in cutaneous squamous cell carcinoma tissues and increased expression of LINC00319 implies a potential link with poor prognosis in cutaneous squamous cell carcinoma patients. LINC00319 exerts its oncogenic functions in cutaneous squamous cell carcinoma through miR-1207-5p-mediated regulation of CDK3. (PMID:30145798)
• Data show that LINC00319 expression is up-regulated in nasopharyngeal carcinoma (NPC) tissues and cells, and its overexpression is associated with poor prognosis. Its knockdown exerts tumor-suppressive role by repressing NPC cell proliferation and tumor growth. Furthermore, LINC00319 functions through functioning as a ceRNA for miR-1207, releasing the miR-1207 inhibitory role for its target gene KLF12. (PMID:30243935)
• LINC00319 promotes ovarian cancer progression through upregulating NACC1 expression by restraining miR-423-5p. (PMID:30442370)
• function role and underlying mechanism of LINC00319 in glioma (PMID:31325436)
• LINC00319 expedited growth and metastasis of gastric cancer by upregulating miR-335-5p-mediated ADCY3 expression. (PMID:31433213)
• Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis. (PMID:31608995)
• LINC00319 promotes osteosarcoma progression by regulating the miR-455-3p/NFIB axis. (PMID:32621625)
• LINC00319 promotes cancer stem cell-like properties in laryngeal squamous cell carcinoma via E2F1-mediated upregulation of HMGB3. (PMID:34408262)
• LINC00319: Unraveling the spectrum from gene regulation to clinical applications in cancer progression. (PMID:38042213)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.