LINC00320

Summary

LINC00320 (long intergenic non-protein coding RNA 320, HGNC:19690) is a long non-coding RNA gene on chromosome 21q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19690
Approved symbol	LINC00320
Name	long intergenic non-protein coding RNA 320
Location	21q21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRED14, FLJ37539
Ensembl gene	ENSG00000224924
Ensembl biotype	lncRNA
Entrez	387486
RNAcentral	URS000075D792 — lncRNA, 2019 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 89 — 89 lncRNA

ENST00000416768, ENST00000419299, ENST00000435279, ENST00000437238, ENST00000452561, ENST00000652807, ENST00000653294, ENST00000653863, ENST00000654018, ENST00000654371, ENST00000654618, ENST00000654836, ENST00000655010, ENST00000655207, ENST00000655298, ENST00000655525, ENST00000655551, ENST00000655781, ENST00000655949, ENST00000655997, ENST00000656151, ENST00000656294, ENST00000656404, ENST00000658084, ENST00000658250, ENST00000658406, ENST00000658509, ENST00000658569, ENST00000658703, ENST00000659193, ENST00000659277, ENST00000659325, ENST00000659386, ENST00000659911, ENST00000659998, ENST00000660140, ENST00000660247, ENST00000660599, ENST00000661350, ENST00000661917, ENST00000663052, ENST00000663053, ENST00000663293, ENST00000663537, ENST00000664349, ENST00000664379, ENST00000665333, ENST00000665378, ENST00000665419, ENST00000665470, ENST00000665477, ENST00000665548, ENST00000665709, ENST00000665727, ENST00000665849, ENST00000665918, ENST00000666206, ENST00000666222, ENST00000666608, ENST00000666665, ENST00000666757, ENST00000667018, ENST00000667667, ENST00000667679, ENST00000668142, ENST00000669117, ENST00000669197, ENST00000669337, ENST00000669643, ENST00000669863, ENST00000670141, ENST00000670351, ENST00000670578, ENST00000670750, ENST00000670894, ENST00000671000, ENST00000671660, ENST00000688468, ENST00000700928, ENST00000701102, ENST00000701250, ENST00000701262, ENST00000701305, ENST00000701638, ENST00000730864, ENST00000730865, ENST00000730866, ENST00000730867, ENST00000730868

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416768 — 7 exons

Exon	Start	End
ENSE00001592770	20742590	20743833
ENSE00001615265	20781349	20781474
ENSE00001647771	20781570	20781661
ENSE00001704275	20782307	20782442
ENSE00001729872	20802995	20803084
ENSE00001735445	20786036	20786088
ENSE00001748536	20778418	20778547

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 92.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 2.1717 / max 430.6084, expressed in 86 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189901	2.1321	86
189902	0.0395	25

Top tissues by expression

200 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	92.34	gold quality
corpus callosum	UBERON:0002336	91.97	gold quality
medial globus pallidus	UBERON:0002477	91.94	gold quality
amygdala	UBERON:0001876	91.36	gold quality
Ammon’s horn	UBERON:0001954	89.75	gold quality
spinal cord	UBERON:0002240	89.26	gold quality
putamen	UBERON:0001874	89.11	gold quality
globus pallidus	UBERON:0001875	88.85	gold quality
substantia nigra	UBERON:0002038	88.22	gold quality
caudate nucleus	UBERON:0001873	87.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	87.40	gold quality
hypothalamus	UBERON:0001898	86.59	gold quality
anterior cingulate cortex	UBERON:0009835	85.82	gold quality
midbrain	UBERON:0001891	85.30	gold quality
buccal mucosa cell	CL:0002336	84.69	gold quality
Brodmann (1909) area 46	UBERON:0006483	84.54	gold quality
temporal lobe	UBERON:0001871	84.49	gold quality
nucleus accumbens	UBERON:0001882	84.37	gold quality
right frontal lobe	UBERON:0002810	84.21	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	84.21	gold quality
prefrontal cortex	UBERON:0000451	83.75	gold quality
forebrain	UBERON:0001890	82.97	gold quality
cerebral cortex	UBERON:0000956	82.63	gold quality
neocortex	UBERON:0001950	81.98	gold quality
frontal cortex	UBERON:0001870	81.88	gold quality
brain	UBERON:0000955	81.10	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.16	gold quality
postcentral gyrus	UBERON:0002581	77.95	gold quality
entorhinal cortex	UBERON:0002728	77.32	gold quality
superior frontal gyrus	UBERON:0002661	75.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• demonstrated the tumor suppressive lncRNA, Linc00320, is down-regulated in Glioma tissues and inhibits Glioma cell proliferation by restraining Wnt/beta-catenin signaling through segregating beta-catenin and TCF4 and revealed the novel HMGB1/Linc00320/beta-catenin axis in Glioma progression (PMID:30503496)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.