LINC00324

Summary

LINC00324 (long intergenic non-protein coding RNA 324, HGNC:26628) is a long non-coding RNA gene on chromosome 17p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26628
Approved symbol	LINC00324
Name	long intergenic non-protein coding RNA 324
Location	17p13.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ34790, MGC104931, TP53LC03, RNA00324
Ensembl gene	ENSG00000178977
Ensembl biotype	lncRNA
Entrez	284029
RNAcentral	URS000075A69B — tRNA, 2115 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000315707, ENST00000813591, ENST00000813592, ENST00000813593

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000315707 — 3 exons

Exon	Start	End
ENSE00001235160	8223812	8224043
ENSE00004213834	8220616	8221509
ENSE00004213839	8222293	8223274

Expression profiles

Bgee: expression breadth ubiquitous, 179 present calls, max score 85.58.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2896 / max 24.7539, expressed in 128 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
164424	0.2896	128

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	85.58	gold quality
granulocyte	CL:0000094	84.76	gold quality
ileal mucosa	UBERON:0000331	84.06	gold quality
leukocyte	CL:0000738	81.41	gold quality
monocyte	CL:0000576	81.15	gold quality
blood	UBERON:0000178	79.97	gold quality
epithelium of nasopharynx	UBERON:0001951	74.76	silver quality
jejunal mucosa	UBERON:0000399	73.81	gold quality
mucosa of paranasal sinus	UBERON:0005030	73.07	gold quality
lymph node	UBERON:0000029	73.05	gold quality
trabecular bone tissue	UBERON:0002483	72.66	silver quality
upper leg skin	UBERON:0004262	72.29	gold quality
pancreatic ductal cell	CL:0002079	71.84	silver quality
spleen	UBERON:0002106	71.76	gold quality
bone marrow	UBERON:0002371	71.76	gold quality
vermiform appendix	UBERON:0001154	70.46	gold quality
bone marrow cell	CL:0002092	70.08	silver quality
stromal cell of endometrium	CL:0002255	69.60	gold quality
duodenum	UBERON:0002114	69.46	gold quality
corpus epididymis	UBERON:0004359	68.09	gold quality
rectum	UBERON:0001052	68.05	gold quality
mucosa of transverse colon	UBERON:0004991	67.09	gold quality
right lobe of liver	UBERON:0001114	66.78	gold quality
gall bladder	UBERON:0002110	66.77	gold quality
skin of leg	UBERON:0001511	66.45	gold quality
amniotic fluid	UBERON:0000173	66.30	gold quality
palpebral conjunctiva	UBERON:0001812	66.21	gold quality
upper arm skin	UBERON:0004263	66.09	gold quality
tibialis anterior	UBERON:0001385	65.88	silver quality
zone of skin	UBERON:0000014	65.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• LINC00324 acted as an oncogene in tumorigenesis and progression, suggesting that it could be a new biomarker in diagnosis and prognosis of Gastric cancer. (PMID:29915327)
• LINC00324 accelerates the proliferation and migration of osteosarcoma through regulating WDR66. (PMID:31225659)
• The expression of LINC00324 in peripheral blood leukocytes of acute myeloid leukemia patients was down-regulated, and its expression level was significantly correlated with immunophenotype CD33, red blood cell and platelet count. (PMID:31750827)
• Knockdown of long non-coding RNA LINC00324 inhibits proliferation, migration and invasion of colorectal cancer cell via targeting miR-214-3p. (PMID:31858541)
• Long noncoding RNA LINC00324 exerts protumorigenic effects on liver cancer stem cells by upregulating fas ligand via PU box binding protein. (PMID:32128906)
• Long intergenic non-protein coding RNA 324 prevents breast cancer progression by modulating miR-10b-5p. (PMID:32305959)
• Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway. (PMID:32633374)
• LINC00324 affects non-small cell lung cancer cell proliferation and invasion through regulation of the miR-139-5p/IGF1R axis. (PMID:32734536)
• Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p. (PMID:33318312)
• LINC00324 facilitates cell proliferation through competing for miR2145p in immature ovarian teratocarcinoma. (PMID:33416104)
• LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells. (PMID:33511550)
• LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway. (PMID:34322788)
• A concise review on the role of LINC00324 in different cancers. (PMID:36399929)
• LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway. (PMID:36493845)
• A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression. (PMID:37480565)
• Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p. (PMID:38059417)
• Dysregulation of LINC00324 promotes poor prognosis in patients with glioma. (PMID:38530810)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.