LINC00326

Summary

LINC00326 (long intergenic non-protein coding RNA 326, HGNC:41926) is a long non-coding RNA gene on chromosome 6q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41926
Approved symbol	LINC00326
Name	long intergenic non-protein coding RNA 326
Location	6q23.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231023
Ensembl biotype	lncRNA
Entrez	285735
RNAcentral	URS000075EFD5 — lncRNA, 1230 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 42 — 42 lncRNA

ENST00000434443, ENST00000457339, ENST00000654682, ENST00000655865, ENST00000656014, ENST00000656106, ENST00000659399, ENST00000662971, ENST00000664900, ENST00000665546, ENST00000666729, ENST00000666914, ENST00000667586, ENST00000668229, ENST00000669115, ENST00000670646, ENST00000670829, ENST00000670892, ENST00000701846, ENST00000787813, ENST00000787814, ENST00000787815, ENST00000787816, ENST00000787817, ENST00000787818, ENST00000787819, ENST00000787820, ENST00000787821, ENST00000787822, ENST00000787823, ENST00000787824, ENST00000787825, ENST00000787826, ENST00000787827, ENST00000787828, ENST00000787829, ENST00000787830, ENST00000787831, ENST00000787832, ENST00000787833, ENST00000787834, ENST00000787835

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434443 — 5 exons

Exon	Start	End
ENSE00001649611	133088120	133088577
ENSE00001713112	133106095	133106417
ENSE00001769387	133096510	133096563
ENSE00002019006	133100007	133100184
ENSE00003852272	133098270	133098382

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 97.00.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1121 / max 61.2886, expressed in 31 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
204209	0.0350	9
69834	0.0245	9
69832	0.0230	9
69833	0.0165	6
69836	0.0084	1
69835	0.0047	1

Top tissues by expression

183 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	97.00	gold quality
bronchial epithelial cell	CL:0002328	85.95	gold quality
bronchus	UBERON:0002185	84.28	gold quality
mucosa of paranasal sinus	UBERON:0005030	82.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.59	gold quality
buccal mucosa cell	CL:0002336	81.55	silver quality
right testis	UBERON:0004534	77.83	gold quality
left testis	UBERON:0004533	77.64	gold quality
testis	UBERON:0000473	75.96	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.79	gold quality
epithelium of nasopharynx	UBERON:0001951	67.72	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.66	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.35	gold quality
right frontal lobe	UBERON:0002810	64.11	gold quality
Brodmann (1909) area 23	UBERON:0013554	62.48	gold quality
spinal cord	UBERON:0002240	62.11	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.90	gold quality
middle temporal gyrus	UBERON:0002771	60.16	silver quality
primary visual cortex	UBERON:0002436	59.59	gold quality
prefrontal cortex	UBERON:0000451	59.56	gold quality
anterior cingulate cortex	UBERON:0009835	58.98	gold quality
neocortex	UBERON:0001950	58.31	gold quality
frontal cortex	UBERON:0001870	58.22	gold quality
nasal cavity epithelium	UBERON:0005384	57.21	gold quality
nasal cavity mucosa	UBERON:0001826	57.19	gold quality
right lung	UBERON:0002167	56.31	gold quality
cerebral cortex	UBERON:0000956	56.01	gold quality
corpus callosum	UBERON:0002336	55.88	gold quality
monocyte	CL:0000576	54.63	gold quality
substantia nigra	UBERON:0002038	54.46	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.47
E-HCAD-30	no	159.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/beta-catenin pathway through modulating the miR-657/dickkopf WNT signaling pathway inhibitor 2 axis. (PMID:36747258)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.