LINC00336

Summary

LINC00336 (long intergenic non-protein coding RNA 336, HGNC:33813) is a long non-coding RNA gene on chromosome 6p21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33813
Approved symbol	LINC00336
Name	long intergenic non-protein coding RNA 336
Location	6p21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ43752
Ensembl gene	ENSG00000197251
Ensembl biotype	lncRNA
Entrez	401253
RNAcentral	URS00022AE773 — lncRNA, 2109 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000477984, ENST00000689377, ENST00000738200, ENST00000738201, ENST00000738202, ENST00000738203, ENST00000738204, ENST00000738205, ENST00000738206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000477984 — 2 exons

Exon	Start	End
ENSE00002061436	33586106	33587870
ENSE00004073215	33592997	33593338

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 59.36.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0403 / max 3.3104, expressed in 22 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73173	0.0403	22

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	59.36	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.66	silver quality
myometrium	UBERON:0001296	56.32	silver quality
islet of Langerhans	UBERON:0000006	54.82	gold quality
cortex of kidney	UBERON:0001225	52.03	gold quality
prefrontal cortex	UBERON:0000451	51.32	gold quality
metanephros cortex	UBERON:0010533	49.44	gold quality
lymph node	UBERON:0000029	48.23	gold quality
thyroid gland	UBERON:0002046	47.18	gold quality
blood	UBERON:0000178	47.15	silver quality
calcaneal tendon	UBERON:0003701	47.12	silver quality
right lobe of thyroid gland	UBERON:0001119	46.77	gold quality
gastrocnemius	UBERON:0001388	46.67	silver quality
gall bladder	UBERON:0002110	46.57	silver quality
left lobe of thyroid gland	UBERON:0001120	46.53	gold quality
hindlimb stylopod muscle	UBERON:0004252	46.37	silver quality
nucleus accumbens	UBERON:0001882	46.08	gold quality
kidney	UBERON:0002113	46.07	gold quality
primary visual cortex	UBERON:0002436	46.07	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	45.85	silver quality
frontal cortex	UBERON:0001870	45.83	silver quality
tonsil	UBERON:0002372	45.75	gold quality
putamen	UBERON:0001874	44.91	gold quality
superior frontal gyrus	UBERON:0002661	44.79	silver quality
transverse colon	UBERON:0001157	44.73	silver quality
vermiform appendix	UBERON:0001154	44.65	silver quality
colon	UBERON:0001155	44.51	silver quality
right atrium auricular region	UBERON:0006631	44.47	silver quality
ovary	UBERON:0000992	44.40	silver quality
cerebral cortex	UBERON:0000956	44.31	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA. (PMID:30787392)
• Heterogeneous ozone effects on the DNA methylome of bronchial cells observed in a crossover study. (PMID:32978449)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.