LINC00342

Summary

LINC00342 (long intergenic non-protein coding RNA 342, HGNC:42470) is a long non-coding RNA gene on chromosome 2q11.1.

Biomarker of Huntington’s disease.

Source: NCBI Gene 150759 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42470
Approved symbol	LINC00342
Name	long intergenic non-protein coding RNA 342
Location	2q11.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232931
Ensembl biotype	lncRNA
Entrez	150759
RNAcentral	URS000075C528 — lncRNA, 3128 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000412393, ENST00000448494, ENST00000655069, ENST00000657232, ENST00000659287, ENST00000660416, ENST00000660608, ENST00000660641, ENST00000661329, ENST00000662121, ENST00000663557, ENST00000664191, ENST00000668171, ENST00000824807, ENST00000824808, ENST00000824809

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412393 — 5 exons

Exon	Start	End
ENSE00001658085	95814671	95814776
ENSE00001765590	95813316	95813533
ENSE00001777715	95813909	95813957
ENSE00001805647	95807118	95807302
ENSE00002466369	95814050	95814145

Expression profiles

Bgee: expression breadth ubiquitous, 271 present calls, max score 98.81.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6903 / max 162.8225, expressed in 251 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29696	0.6903	251

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	98.81	gold quality
left testis	UBERON:0004533	98.32	gold quality
right testis	UBERON:0004534	98.26	gold quality
right uterine tube	UBERON:0001302	97.32	gold quality
mucosa of stomach	UBERON:0001199	97.29	gold quality
sural nerve	UBERON:0015488	96.87	gold quality
minor salivary gland	UBERON:0001830	96.74	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.31	gold quality
cerebellar hemisphere	UBERON:0002245	94.98	gold quality
cerebellar cortex	UBERON:0002129	94.91	gold quality
testis	UBERON:0000473	94.83	gold quality
pylorus	UBERON:0001166	93.54	gold quality
saliva-secreting gland	UBERON:0001044	93.42	gold quality
left ovary	UBERON:0002119	93.39	gold quality
right ovary	UBERON:0002118	93.13	gold quality
cerebellum	UBERON:0002037	92.80	gold quality
body of pancreas	UBERON:0001150	92.25	gold quality
mouth mucosa	UBERON:0003729	92.12	gold quality
body of stomach	UBERON:0001161	92.00	gold quality
right frontal lobe	UBERON:0002810	91.97	gold quality
adenohypophysis	UBERON:0002196	91.90	gold quality
nucleus accumbens	UBERON:0001882	91.79	gold quality
tibial nerve	UBERON:0001323	91.73	gold quality
caudate nucleus	UBERON:0001873	91.54	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.50	gold quality
stomach	UBERON:0000945	91.30	gold quality
body of uterus	UBERON:0009853	91.24	gold quality
tendon	UBERON:0000043	91.17	gold quality
pituitary gland	UBERON:0000007	91.08	gold quality
medial globus pallidus	UBERON:0002477	90.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• LINC00342 is involved in the development, and LINC00342 may be a potential diagnostic factor and a target for new therapies for future patients with non-small cell lung cancer. (PMID:30320899)
• Long noncoding RNA LINC00342 promotes growth of infantile hemangioma by sponging miR-3619-5p from HDGF. (PMID:31469292)
• LncRNA LINC00342 regulated cell growth and metastasis in non-small cell lung cancer via targeting miR-203a-3p. (PMID:31539128)
• LINC00342 was over-expressed in colon adenocarcinoma (COAD) tissues and was related to the poor prognosis. LINC00342 knockdown inhibited cell proliferation, migration and invasion and promoted apoptosis of COAD cells. LINC00342 targeted to miR-545-5p/ MDM2 in COAD. In COAD tissues and cell lines, LINC00342 expression was positively correlated to MDM2 expression, while it was negatively correlated to miR-545-5p expression. (PMID:32213297)
• LncRNA LINC00342 promotes gastric cancer progression by targeting the miR-545-5p/CNPY2 axis. (PMID:34715819)
• LINC00342 induces metastasis of lung adenocarcinoma by targeting miR-15b/TPBG. (PMID:35452205)
• [Biological function and clinical significance of long non-coding RNA LINC00342 in head and neck squamous carcinoma]. (PMID:36878503)
• [LncRNA LINC00342 regulates gastric cancer cell proliferation, migration and invasion by targeting miR-596]. (PMID:37933652)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.