LINC00355

Summary

LINC00355 (long intergenic non-protein coding RNA 355, HGNC:27061) is a long non-coding RNA gene on chromosome 13q21.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27061
Approved symbol	LINC00355
Name	long intergenic non-protein coding RNA 355
Location	13q21.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227674
Ensembl biotype	lncRNA
Entrez	144766
RNAcentral	URS0000158102 — lncRNA, 1878 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000456627, ENST00000650541, ENST00000654282, ENST00000669788

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456627 — 6 exons

Exon	Start	End
ENSE00001422653	63986371	63987039
ENSE00001637192	64003348	64003465
ENSE00001639317	64002385	64002409
ENSE00001685608	63990096	63990200
ENSE00001723759	64075242	64076011
ENSE00001761432	64034347	64034537

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 71.40.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3566 / max 23.9546, expressed in 126 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137484	0.2197	102
137485	0.1370	71

Top tissues by expression

192 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	71.40	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	63.00	gold quality
cortical plate	UBERON:0005343	59.53	gold quality
ganglionic eminence	UBERON:0004023	58.72	gold quality
monocyte	CL:0000576	54.53	gold quality
cortex of kidney	UBERON:0001225	53.60	gold quality
medial globus pallidus	UBERON:0002477	53.08	gold quality
globus pallidus	UBERON:0001875	50.26	gold quality
prefrontal cortex	UBERON:0000451	49.30	silver quality
blood	UBERON:0000178	49.12	gold quality
right lobe of liver	UBERON:0001114	48.49	silver quality
muscle of leg	UBERON:0001383	47.12	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	46.76	gold quality
gastrocnemius	UBERON:0001388	46.52	silver quality
ectocervix	UBERON:0012249	46.23	gold quality
cerebellar cortex	UBERON:0002129	46.16	silver quality
cerebellar hemisphere	UBERON:0002245	46.04	silver quality
deltoid	UBERON:0001476	46.03	gold quality
cerebellum	UBERON:0002037	45.50	silver quality
vermiform appendix	UBERON:0001154	45.17	silver quality
islet of Langerhans	UBERON:0000006	44.84	silver quality
heart left ventricle	UBERON:0002084	44.59	gold quality
pancreas	UBERON:0001264	44.55	silver quality
right hemisphere of cerebellum	UBERON:0014890	44.42	silver quality
cardiac ventricle	UBERON:0002082	44.19	gold quality
Brodmann (1909) area 9	UBERON:0013540	43.64	silver quality
frontal cortex	UBERON:0001870	43.63	silver quality
neocortex	UBERON:0001950	43.55	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
tibial artery	UBERON:0007610	43.31	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• A novel long non-coding RNA LINC00355 promotes proliferation of lung adenocarcinoma cells by down-regulating miR-195 and up-regulating the expression of CCNE1. (PMID:31689506)
• Cancer-associated fibroblasts-derived exosomes-mediated transfer of LINC00355 regulates bladder cancer cell proliferation and invasion. (PMID:31749189)
• LINC00355 inhibits apoptosis and promotes proliferation of gastric cancer cells by regulating Wnt/beta-catenin signaling pathway. (PMID:32894544)
• LINC00355 promoted the progression of lung squamous cell carcinoma through regulating the miR-466/LYAR axis. (PMID:33111744)
• Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistance to cisplatin by regulating miR-34b-5p/ABCB1 axis. (PMID:33720323)
• Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell proliferation and invasion by regulating miR-15a-5p/HMGA2 axis. (PMID:33882126)
• LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p. (PMID:34078310)
• lncRNA LINC00355 Acts as a Novel Biomarker and Promotes Glioma Biological Activities via the Regulation of miR-1225/FNDC3B. (PMID:34603558)
• LncRNA LINC00355 promotes EMT and metastasis of bladder cancer cells through the miR-424-5p/HMGA2 axis. (PMID:34641698)
• Exosomal LINC00355 promotes the malignant progression of gastric cancer through histone deacetylase HDAC3-mediated TP53INP1 transcriptional inhibition. (PMID:36640904)
• LINC00355 Mediates CTNNBIP1 Promoter Methylation and Promotes Endoplasmic Reticulum Stress-Induced Podocyte Injury in Diabetic Nephropathy. (PMID:36738224)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.