LINC00365

Summary

LINC00365 (long intergenic non-protein coding RNA 365, HGNC:42687) is a long non-coding RNA gene on chromosome 13q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42687
Approved symbol	LINC00365
Name	long intergenic non-protein coding RNA 365
Location	13q12.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224511
Ensembl biotype	lncRNA
Entrez	100874146
RNAcentral	URS00008E3A14 — lncRNA, 2625 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000413591, ENST00000432770, ENST00000660467, ENST00000837161, ENST00000837162

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413591 — 2 exons

Exon	Start	End
ENSE00004257345	30108769	30108934
ENSE00004257348	30103178	30105695

Expression profiles

Bgee: expression breadth ubiquitous, 106 present calls, max score 84.75.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0678 / max 5.3399, expressed in 34 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
136621	0.0678	34

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	84.75	gold quality
testis	UBERON:0000473	77.01	gold quality
body of stomach	UBERON:0001161	71.94	gold quality
stomach	UBERON:0000945	71.56	gold quality
fundus of stomach	UBERON:0001160	71.42	gold quality
ventricular zone	UBERON:0003053	67.26	gold quality
bone marrow cell	CL:0002092	64.06	silver quality
liver	UBERON:0002107	62.69	gold quality
islet of Langerhans	UBERON:0000006	62.27	gold quality
cortical plate	UBERON:0005343	62.25	gold quality
ganglionic eminence	UBERON:0004023	62.05	gold quality
right lobe of liver	UBERON:0001114	61.55	gold quality
rectum	UBERON:0001052	60.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	59.18	gold quality
gall bladder	UBERON:0002110	59.00	gold quality
duodenum	UBERON:0002114	58.46	gold quality
bone marrow	UBERON:0002371	57.17	silver quality
pancreas	UBERON:0001264	56.92	gold quality
monocyte	CL:0000576	56.83	gold quality
muscle tissue	UBERON:0002385	56.08	gold quality
mucosa of stomach	UBERON:0001199	55.12	gold quality
right uterine tube	UBERON:0001302	54.28	gold quality
vermiform appendix	UBERON:0001154	53.49	gold quality
skeletal muscle tissue	UBERON:0001134	53.23	silver quality
placenta	UBERON:0001987	52.82	gold quality
blood	UBERON:0000178	52.09	gold quality
body of pancreas	UBERON:0001150	51.92	gold quality
lung	UBERON:0002048	51.83	gold quality
upper lobe of left lung	UBERON:0008952	51.57	gold quality
right lung	UBERON:0002167	50.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• A competing endogenous RNA network composed of 70 miRNAs, nine mRNAs, and LINC00365 was constructed. Eight of nine mRNAs were validated upregulated in The Cancer Genome Atlas data set. Our results suggested that LINC00365 was an oncogene in Colorectal cancer (CRC) and it could regulate the expression of several mRNAs through sponging miRNAs. (PMID:30525245)
• LINC00365 promotes colorectal cancer cell progression through the Wnt/beta-catenin signaling pathway. (PMID:31544991)
• LINC00365 functions as a tumor suppressor by inhibiting HIF-1alpha-mediated glucose metabolism reprogramming in breast cancer. (PMID:36804531)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.